1. Anti-Hypersensitivity

Anti-Hypersensitivity

 

 

In addition to the onset of smear layer formation, the durability of the tubule occlusions also impacts the effectiveness of the anti-hypersensitivity agent. Stabilized stannous fluoride dentifrice forms a smear layer that is resistant to both daily mechanical and acid challenges. Figure 15 compares a stabilized stannous fluoride dentifrice to two other anti-hypersensitivity toothpastes which also act by a tubule occlusion mechanism. The smear layer of the stabilized stannous fluoride dentifrice is more resistant to a dietary acid challenge than that of either of the other products (Zsiska et al. 2011).

Fluid movement in open dentinal tubules

Figure 12. Fluid movement in open dentinal tubules

Mechanism of action of stabilized stannous fluoride dentifrice

Early treatments using solutions and later gels demonstrated the desensitizing effect of stannous fluoride. The dentinal tubules are occluded by precipitated stannous salts, inhibiting fluid movement within the tubules and thereby preventing nerve stimulation and pain (Figures 13, 14; Miller et al. 1994; Thrash et al. 1995).

The effective occlusion of dentinal tubules with stabilized stannous fluoride dentifrice
Pre-and posttreatment with open and occluded dentinal tubules

Figure 13. Dentinal tubule occlusion: Note the effective occlusion of dentinal tubules with stabilized stannous fluoride dentifrice (SEM x2000)

Figure 14. Pre-and post-brushing SEMs: pre-and post-treatment with open and occluded dentinal tubules Courtesy of Cosmetics & Toiletries

Relative dentinal tubule occlusion for stabilized stannous fluoride dentifrice versus two other anti-hypersensitivity dentifrices after treatment, mechanical agitation, and one minute acid exposure

Figure 15. Relative dentinal tubule occlusion for stabilized stannous fluoride dentifrice versus two other anti-hypersensitivity dentifrices after treatment, mechanical agitation, and one minute acid exposure.

 

 

In addition to the onset of smear layer formation, the durability of the tubule occlusions also impacts the effectiveness of the anti-hypersensitivity agent. Stabilized stannous fluoride dentifrice forms a smear layer that is resistant to both daily mechanical and acid challenges. Figure 15 compares a stabilized stannous fluoride dentifrice to two other anti-hypersensitivity toothpastes which also act by a tubule occlusion mechanism. The smear layer of the stabilized stannous fluoride dentifrice is more resistant to a dietary acid challenge than that of either of the other products (Zsiska et al. 2011).

Stannous fluoride protects against dentinal hypersensitivity
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