1. A Clinical Trial to Assess Plaque Prevention with Use of a Daily Two-Step Dentifrice and Gel System

A Clinical Trial to Assess Plaque Prevention with Use of a Daily Two-Step Dentifrice and Gel System

Reference: García-Godoy C, Duque N, Rothrock JA. J Dent Res 2016; 95 (Spec Iss A): Abstract 1708.

KEY CLINICAL FINDINGS

The two-step dentifrice and gel system group had significantly (P≤0.011) less overnight (prebrush) percent plaque area than the control group at Week 1 (52.9%) and Week 2 (45%). See Figures 1 & 2. Step 1 is a 0.454% stannous fluoride dentifrice and Step 2 is a 3% hydrogen peroxide whitening gel.

Figure 1. Mean Overnight (Pre-Brush) Percent Plaque Area

Mean Overnight (Pre-Brush) Percent Plaque Area

Figure 2. Representative response of overnight plaque coverage at Week 1

Representative response of overnight plaque coverage at Week 1

OBJECTIVE

To assess plaque area following a dental prophylaxis and twice daily use of a 2-step dentifrice and gel system versus a standard oral hygiene control.

METHODS

  • This was a randomized, controlled, examiner-blind, 2-treatment parallel group plaque prevention study among healthy adult volunteers with plaque.
  • Following a whole-mouth dental prophylaxis, subjects were randomized to one of two groups:
  • - Standard oral hygiene control group: 0.76% sodium monofluorophosphate dentifrice (Colgate® Cavity Protection, Colgate-Palmolive) and a soft, regular manual toothbrush (Oral-B® Indicator, Procter & Gamble)

    or

    - 2-step dentifrice and gel system (Crest® PRO-HEALTH [HD]™, Procter & Gamble): Step 1, 0.454% stannous fluoride dentifrice; Step 2, 3% hydrogen peroxide whitening gel. The system was used with a soft, regular manual toothbrush (Oral-B® Indicator).

     

  • Overnight percent plaque area was assessed after 1 and 2 weeks of treatment by digital image analysis of fluorescein-disclosed plaque.
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