1. Comparative Anti-plaque Effect of Stabilized Stannous Fluoride and Triclosan Dentifrices

Comparative Anti-plaque Effect of Stabilized Stannous Fluoride and Triclosan Dentifrices

Reference: Friesen L, Goyal CR, Qaqish J, et al. J Dent Res 2017; 96 (Spec Iss A): Abstract 0214.

KEY CLINICAL FINDINGS

  • After 4 weeks of use, the stabilized stannous fluoride (SnF2) dentifrice group had 23.1% lower whole mouth plaque scores and 43.5% lower interproximal plaque scores than the triclosan positive control dentifrice group (P <0.0001). See Figures 1 and 2.
  • Both the triclosan and SnF2 dentifrice groups demonstrated statistically significant (P<0.0001) reductions in plaque levels at Week 4 versus Baseline.
  • Both treatments were well tolerated.

Figure 1. Whole mouth plaque scores at Baseline and Week 4.

Whole mouth plaque scores at Baseline and Week 4.

N=118. *Statistically significant difference between groups, P<0.0001. **Week 4 values are adjusted means.

Figure 2. Interproximal plaque scores at Baseline and Week 4.

Interproximal plaque scores at Baseline and Week 4.

OBJECTIVE

To compare the effect of a SnF2 dentifrice versus triclosan dentifrice on reduction of plaque over a 4-week period.

STUDY DESIGN

  • This was a randomized, parallel, double-blind, 4-week clinical trial including subjects with evidence of plaque.
  • Subjects were randomized to one of two treatment groups:
  • - Experimental 0.454% stabilized SnF2 dentifrice (Crest® PRO-HEALTH Clean Mint [Smooth Formula], Procter & Gamble)

    or

    - Triclosan positive control dentifrice with 0.24% sodium fluoride (Colgate® Total®, Colgate-Palmolive). Both groups used a soft, regular manual toothbrush (American Dental Association) and brushed with their respective product according to manufacturer’s instructions at-home.

     

  • Plaque was evaluated using the Rustogi Modification of the Navy Plaque Index (RMNPI) at Baseline and after 4 weeks of product use.
  • Statistical analyses utilized analysis of covariance with baseline value as covariate.

CLINICAL COMMENT

Chemotherapeutic antimicrobial dentifrices play an important role in the control of plaqueinduced oral diseases, such as gingivitis. Both SnF2 and triclosan dentifrices have been shown to provide significant inhibition of plaque.1,2 This study showed the new smooth formula SnF2 dentifrice provided significantly greater plaque control than the triclosan dentifrice. These findings are consistent with other studies in the literature showing superior plaque protection for SnF2 versus triclosan dentifrice.3,4

1White DJ, et al. J Contemp Dent Pract. 2006;July (7)3:001-011.
2Rover JA, et al. Am J Dent. 2014 Jun;27(3):167-70.
3He T, et al. Am J Dent. 2013;26: 303-306.
4Sharma NC et al. J Clin Dent. 2013;24:31-36.

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