1. Desensitizing Effect of a Stabilized Stannous Fluoride Dentifrice

Desensitizing Effect of a Stabilized Stannous Fluoride Dentifrice

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Reference: Schiff T, Saletta L, Baker RA, et al. Compend Contin Educ Dent. 2005;26(9 suppl 1):35-40.

CONCLUSION

Crest® PRO-HEALTH showed a clinically and statistically significant decrease in hypersensitivity compared to a negative control dentifrice.

OBJECTIVE

To evaluate the desensitizing properties of Crest® PRO-HEALTH compared to a negative control dentifrice.

MATERIALS AND METHODS

  • Crest® PRO-HEALTH (0.454% stabilized stannous fluoride dentifrice with sodium hexametaphosphate for cosmetic benefits) was compared to a marketed negative control dentifrice containing 0.243% sodium fluoride (Crest® Cavity Protection).
  • Study subjects were adults with a minimum of 2 bicuspid/cuspid teeth with sensitivity criteria of Yeaple Probe Index = 10 g and Schiff Air Sensitivity Scale score of >1.
  • Experimental 0.454% stabilized SnF2 dentifrice (Crest® PRO-HEALTH Clean Mint [Smooth Formula], Procter & Gamble)
  • Tooth sensitivity was measured by tactile examination using the Yeaple probe and thermal examination using the Schiff Air Index.
  • Oral soft tissue examinations were conducted and adverse events recorded.
  • Subjects were randomized to either the stabilized stannous fluoride dentifrice or the control dentifrice.
  • Subjects brushed twice daily with their assigned dentifrice using a manual soft toothbrush for 8 weeks.
  • Subjects were examined again for tooth sensitivity and safety at weeks 4 and 8.

RESULTS

  • Data were analyzed for 77 subjects who had complete data.
  • Yeaple Probe Index scores were statistically significantly higher for the stabilized stannous fluoride group than the sodium fluoride control group at both weeks 4 and 8 (P<0.0001). Higher Yeaple Probe Index scores indicate less tooth sensitivity.
  • Compared to the sodium fluoride control group, the stabilized stannous fluoride group had a mean Yeaple Probe Index score 1.6 times that of the sodium fluoride group at week 4 and 2 times at week 8.
  • Schiff Air Index scores were statistically significantly lower for the stabilized stannous fluoride group than the sodium fluoride control group at both weeks 4 and 8 (P<0.0001). Lower Schiff Air Index scores indicate less tooth sensitivity.
  • Compared to the sodium fluoride control group, the stabilized stannous fluoride group showed a 36% lower Schiff Air Index score (adjusted mean) than the sodium fluoride group at week 4 and a 44% lower score at week 8.
  • No adverse events were reported or observed.
Adjusted Mean Schiff Air Index Score

Lower Schiff Air Index scores indicate less tooth sensitivity

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