1. Effects of 0.454% SnF2 Dentifrice on Daytime and Overnight Malodor

Effects of 0.454% SnF2 Dentifrice on Daytime and Overnight Malodor

Reference: Farrell S, Gerlach RW, Barker ML, et al. J Dent Res. 2008;87(spec issue B): abstract 3161.

CONCLUSION

The use of the 0.454% stabilized stannous fluoride dentifrice resulted in significant reduction in short-term and long-term daytime and overnight malodor relative to a control dentifrice.

OBJECTIVE

A clinical study was conducted to evaluate daytime and overnight oral malodor reduction benefit of a 0.454% stabilized stannous fluoride therapeutic dentifrice with short-term and long-term use.

MATERIALS AND METHODS

  • The study was a randomized, double-blinded, 2-treatment, 3-period crossover clinical trial.
  • After completing an acclimation period, 45 subjects with existing oral malodor were randomly assigned to a crossover treatment sequence consisting of Crest® PRO-HEALTH dentifrice (0.454% stabilized stannous fluoride dentifrice) and Crest® Cavity Protection dentifrice (control).
  • For each treatment period, subjects brushed with the assigned product twice a day for 7 days. Oral malodor was assessed on a 9-point hedonic scale at baseline, day 2–overnight, day 2–daytime (4 hours post morning brushing), day 8–overnight, day 8–daytime (4 hours post morning brushing). Treatment periods were separated by washout periods during which subjects brushed with the control dentifrice.

RESULTS

  • Subjects had a mean age of 39 years, 58% of the subjects were female and the mean baseline hedonic score was 7.4.
  • Relative to the control, use of the stabilized stannous fluoride dentifrice resulted in significant (P<0.002) improvement of the overnight and daytime malodor both short-term at day 2 and long-term at day 8.
  • The mean overnight hedonic scores were 3.2 and 5.1 at day 8 after 1 week of brushing for the stabilized stannous fluoride and the control dentifrices, respectively. The mean daytime hedonic scores were 2.4 and 4.1 at day 8 for the stabilized stannous fluoride and the control dentifrices, respectively.
Mean Hedonic Scores Day 8
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