1. Extrinsic Stain Removal Efficacy of a Stannous Fluoride Dentifrice With Sodium Hexametaphosphate

Extrinsic Stain Removal Efficacy of a Stannous Fluoride Dentifrice With Sodium Hexametaphosphate

Reference: He T, Baker R, Bartizek RD, et al. J Clin Dent. 2007;18(1):7-11.

CONCLUSION

In 2 studies, Crest® PRO-HEALTHdemonstrated significant extrinsic stain removal vs baseline and comparable stain removal to the positive control dentifrice.

Also refer to A Randomized Clinical Trial to Assess Gingivitis, Plaque, and Tooth Color after Use of a Daily Two-Step Dentifrice and Gel System versus Chlorhexidine Rinse, Page 20.

OBJECTIVE

To compare stain removal of a dentifrice containing stabilized stannous fluoride and sodium hexametaphosphate to a positive control dentifrice in 2 independent, double-blind, randomized 6-week trials.

The following dentifrices were tested in each study:

  • Crest® PRO-HEALTH (0.454% stabilized stannous fluoride + sodium hexametaphosphate).
  • Positive control dentifrice (Colgate Total Plus Whitening with sodium fluoride).

MATERIALS AND METHODS

  • Both studies followed the same protocol.
  • Study subjects were healthy adults with visible extrinsic tooth stain.
  • The modified Lobene Stain Index was used to measure stain on the facial surfaces of the 8 central and lateral incisors at baseline.
  • Oral soft and hard tissue examinations were also conducted.
  • Subjects were randomized to either the stabilized stannous fluoride + sodium hexametaphosphate toothpaste or positive control toothpaste.
  • Subjects used their assigned dentifrice twice a day for 6 weeks.
  • Patients were examined again for stain and safety at weeks 3 and 6.

RESULTS

  • 52 subjects completed Study 1; 58 subjects completed Study 2
  • Lobene composite stain scores were not statistically significantly different between the 2 dentifrice groups at all 3 time points (baseline, week 3, and week 6) in each study.
  • Relative to baseline scores, both dentifrice groups showed statistically significant reductions in Lobene composite stain scores at week 3 (P<0.0001) and week 6 (P<0.0001).

Study 1. Lobene Composite Stain Score, Evaluable Subjects

Lobene Composite Stain Score, Evaluable Subjects

Study 2. ILobene Composite Stain Score, Evaluable Subjects

Lobene Composite Stain Score, Evaluable Subjects, Week 3 and 6
  • Page 52 of 56