1. Oral Malodor Reduction With 3-Week Use of 0.454% SnF2 Dentifrice

Oral Malodor Reduction With 3-Week Use of 0.454% SnF2 Dentifrice

Reference: Nachnani S, La S, Lee S, et al. J Dent Res. 2008;87(spec issue B):abstract 2864.

CONCLUSION

The use of the 0.454% stabilized stannous fluoride dentifrice resulted in significant reduction in short-term and long-term daytime and overnight malodor relative to a control dentifrice.

OBJECTIVE

This clinical study evaluated the effects of the 3-week use of a 0.454% stabilized stannous fluoride therapeutic dentifrice on oral malodor.

MATERIALS AND METHODS

  • The study was a randomized, double-blinded, 2-treatment, parallel design clinical trial.
  • After completing an acclimation period, 71 subjects with existing oral malodor were randomized to 1 of the 2 treatments: 0.454% stabilized stannous fluoride dentifrice (Crest® PRO-HEALTH) or Crest® Cavity Protection dentifrice (control). Subjects brushed with the assigned product twice a day for 3 weeks.
  • Oral malodor was assessed on a 9-point hedonic scale at baseline, week 1, and week 3.

RESULTS

  • The mean age of study participants was 37.8 years, and 59% were female. The baseline mean hedonic score was 8.19.
  • At week 1, the mean hedonic scores (SE) were 3.40 (0.18) and 6.62 (0.18) for the stabilized stannous fluoride dentifrice and the control dentifrice, respectively.
  • At week 3, the mean hedonic scores (SE) were 1.55 (0.18) and 5.28 (0.18) for the stabilized stannous fluoride dentifrice and the control dentifrice, respectively.
  • Relative to the control, the use of the stabilized stannous fluoride dentifrice resulted in significantly (P<0.0001) greater reduction in oral malodor at both visits. Both treatments were well tolerated.
Mean Hedonic Scores
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