1. Plaque Control Evaluation of a Stabilized Stannous Fluoride Dentifrice Compared to a Triclosan Dentifrice in a Six-Week Trial

Plaque Control Evaluation of a Stabilized Stannous Fluoride Dentifrice Compared to a Triclosan Dentifrice in a Six-Week Trial

Reference: Sharma N, He T, Barker ML, Biesbrock AR. J Clin Dent 2013;24:31-36

KEY CLINICAL RESULTS

Both the stannous fluoride dentifrice and the triclosan dentifrice produced a statistically significant reduction from baseline in mean plaque values for whole mouth, gingival margin, and interproximal plaque at Weeks 3 and 6 (P < 0.02 for all comparisons).

The stannous fluoride dentifrice showed a statistically significantly (P < 0.0001) lower adjusted mean plaque level compared to the triclosan group for all three tooth areas at both Weeks 3 and 6. Whole mouth plaque scores for the stannous fluoride dentifrice were 29.7% lower at Week 3 and 44.9% lower at Week 6 than the triclosan dentifrice (Figure 1).

Figure 1. Whole mouth plaque levels at Baseline, Week 3 and Week 6 per group.

Whole mouth plaque levels at Baseline

METHODS

  • This was a 6-week, randomized, double-blind, two-treatment, parallel-group clinical trial.
  • Generally healthy adults with baseline plaque levels ≥ 0.5 as assessed by Rustogi, et al. Modified Navy PIaque Index (RMNPI) were randomized to one of the following treatments:
  • - 0.454% stannous fluoride dentifrice (Crest® PRO-HEALTH Advanced Deep Clean, Procter & Gamble)

    or

    - 0.3% triclosan/0.24% sodium fluoride dentifrice (Colgate Total, Colgate-Palmolive)

    Subjects brushed their teeth with a soft manual toothbrush (Oral-B® Indicator, Procter & Gamble) using their assigned treatment dentifrice according to the manufacturer’s instructions.

  • Overnight plaque accumulation was evaluated by an experienced examiner using the RMNPI at baseline, Week 3 and Week 6. Groups were compared using analysis of covariance separately for Weeks 3 and 6, and by repeated measures for Weeks 3 and 6 combined.
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