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Reference: Pfarrer AM, McQueen CM, Lawless MA, Rapozo-Hilo M, Featherstone JDB. Compend Contin Educ Dent. 2005;26(Suppl1):41-46.
In vitro studies demonstrated the anticaries potential of the stabilized stannous fluoride dentifrice.
To examine the anticaries potential of a stabilized stannous fluoride dentifrice with sodium hexametaphosphate (for cosmetic benefits).
In vitro anti-caries profile methods were:
- Stabilized stannous fluoride with sodium hexametaphosphate (1,100 pmm fluoride as stannous fluoride, sodium hexametaphosphate, and silica)
- United States Pharmacopeia (USP) Reference Standard (1,100 pmm fluoride as stannous fluoride and silica)
- Dose-response control USP Reference Standard (diluted to 250 ppm fluoride as stannous fluoride and silica)
- Placebo negative control (<1ppm fluoride and silica)
- Stabilized stannous fluoride with sodium hexametaphosphate
- Sodium fluoride with sodium hexametaphosphate (1,100 pmm fluoride as sodium fluoride, sodium hexametaphosphate, and silica)
- Stannous fluoride USP Reference Standard (1,100 pmm fluoride as stannous fluoride and silica)
- Sodium fluoride USP Reference Standard (1,100 ppm fluoride as sodium fluoride and silica)
- Dose-response sodium fluoride control
- Placebo negative control (<1ppm fluoride)
Human enamel samples from extracted teeth – 3 mm diameter cores – were decalcified for 24 hours to produce early caries lesions 20-30 μm deep. Samples were taken from the cores by the microdrill biopsy technique. Samples were measured for fluoride levels pre-dentifrice treatment. Groups of specimens were treated with dentifrice/saliva slurries. Samples were taken to determine post-treatment fluoride levels. The difference between pre and post levels determined fluoride uptake.
Caries-free human molar or premolar crowns were each treated to produce a 3 x 2 mm window on one surface as the entry point for demineralization. 24-hour test cycles
- 6 hours demineralization, 1 minute dentifrice treatment, 16 hours remineralization, 1 minute treatment – were repeated for 14 days. Cycles were designed to model normal demineralization and remineralization. The resulting lesions were measured for progression into the enamel, and mineral loss from each lesion calculated.
There was no statistically significant difference between the stannous fluoride with sodium hexametaphosphate toothpaste and the stannous fluoride USP Reference Standard toothpaste.
The stannous fluoride with sodium hexametaphosphate toothpaste was at least as good as the clinically proven stannous fluoride and sodium fluoride USP Reference Standard toothpastes.