Pharmacokinetics

Pharmacokinetic principles relate to the fate of drugs within the body.4,5 They are concerned with mechanisms of absorption, distribution (redistribution), metabolism (biotransformation), and excretion or clearance (Figure 7). Pharmacokinetic variable are important determinants of the dosing regimen required for a drug to reach and maintain therapeutic concentrations in the body for optimum efficacy without causing toxicity.

Figure 7.
Pharmacokinetic factors
Pharmacokinetic factors that affect a drug’s ability to reach and maintain therapeutic concentrations in the body for optimum efficacy without causing toxicity.