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Management of Patients with Chronic Diseases

Course Number: 567

References / Additional Resources

  1. CDC. National Center for Chronic Disease Prevention and Health Promotion. About chronic diseases. 2021 Oct 28. Accessed October 28, 2021.

  2. Association of State & Territorial Dental Directors. Chronic disease and medical/dental integration. 2021. Accessed October 28, 2021.

  3. Shi Q, Zhang B, Xing H, et al. Patients with Chronic Obstructive Pulmonary Disease Suffer from Worse Periodontal Health-Evidence from a Meta-Analysis. Front Physiol. 2018 Jan 25;9:33. doi: 10.3389/fphys.2018.00033. eCollection 2018.

  4. Beck J, Philips K, Moss K, et al. Periodontal disease classifications and incident coronary heart disease in the atherosclerosis risk in communities study. J Periodontal. 2020;91:1409-1418. Accessed October 22, 2018.

  5. Bensley L, VanEenwyk J, Ossiander EM. Associations of self-reported periodontal disease with metabolic syndrome and number of self-reported chronic conditions. Prev Chronic Dis. 2011 May;8(3):A50. Epub 2011 Apr 15.

  6. Maldonado A, Laugisch O, Bürgin W, Sculean A, Eick S. Clinical periodontal variables in patients with and without dementia-a systematic review and meta-analysis. Clin Oral Investig. 2018 Sep;22(7):2463-2474. doi: 10.1007/s00784-018-2523-x. Epub 2018 Jun 22. PMID: 29934798.

  7. Chen CK, Wu YT, Chang YC. Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study. Alzheimers Res Ther. 2017 Aug 8;9(1):56. doi: 10.1186/s13195-017-0282-6.

  8. Cheng F, Zhang M, Wang Q, et al. Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies. PLoS One. 2018 Mar 28;13(3):e0194563. doi: 10.1371/journal.pone.0194563. eCollection 2018.

  9. Nascimento GG, Leite FRM, Vestergaard P, et al. Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies. Acta Diabetol. 2018 Jul;55(7):653-667. doi: 10.1007/s00592-018-1120-4. Epub 2018 Mar 3.

  10. Fiske J, Frenkel H, Griffiths J, et al. Guidelines for the development of local standards of oral health care for people with dementia. Gerodontology. 2006 Dec;23 Suppl 1:5-32. doi: 10.1111/j.1741-2358.2006.00140.x.

  11. Pynn TP, Kolic JE. Oral Health and Dementia: Obstacles, Assessments, and Management of Patients with Dementia. Oral Health. 2014 Jun 01. Accessed October 28, 2021.

  12. Branson BG. Tips for Treating Facility-Based Patients. Dimensions of Dental Hygiene. 2013 Nov;11(11):19–22. Accessed October 28, 2021.

  13. CDC. Alzheimer's Disease and Healthy Aging. 2020. Oct 26. Accessed October 28, 2021.

  14. Alzheimer’s Association. 2015 Alzheimer's disease facts and figures. Alzheimers Dement. 2015 Mar;11(3):332-84.

  15. Alzheimer's Association. What is Alzheimer's? 2021. Accessed October 28, 2021.

  16. Alzheimer's Association. 2021 Alzheimer's Disease Facts and Figures. 2021. Accessed October 28, 2021.

  17. MedlinePlus. Alzheimer's Disease. 2019 Oct 21. Accessed October 28, 2021

  18. Blazer DG, Yaffe K, Liverman CT. Cognitive Aging: Progress in Understanding and Opportunities for Action. Committee on the Public Health Dimensions of Cognitive Aging; Board on Health Sciences Policy; Institute of Medicine. Washington (DC): National Academies Press (US); 2015 Jul.

  19. Baumgart M, Snyder HM, Carrillo MC, et al. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimers Dement. 2015 Jun;11(6):718-26. doi: 10.1016/j.jalz.2015.05.016. Epub 2015 Jun 1.

  20. Alzheimer's Association. Dental Care. Daily Care. 2021. Accessed October 28, 2021.

  21. Mancini M, Grappasonni I, Scuri S, et al. Oral health in Alzheimer's disease: a review. Curr Alzheimer Res. 2010 Jun;7(4):368-73.

  22. Cicciù M, Matacena G, Signorino F, et al. Relationship between oral health and its impact on the quality life of Alzheimer's disease patients: a supportive care trial. Int J Clin Exp Med. 2013 Sep 25;6(9):766-72. eCollection 2013.

  23. Vitaliano PP, Persson R, Kiyak A, et al. Caregiving and gingival symptom reports: psychophysiologic mediators. Psychosom Med. 2005 Nov-Dec;67(6):930-8. doi: 10.1097/01.psy.0000188485.65153.7b.

  24. Chalmers JM, Carter KD, Spencer AJ. Oral diseases and conditions in community-living older adults with and without dementia. Spec Care Dentist. 2003;23(1):7-17.

  25. Syrjälä AM, Ylöstalo P, Sulkava R, et al. Relationship between cognitive impairment and oral health: results of the Health 2000 Health Examination Survey in Finland. Acta Odontol Scand. 2007 Apr;65(2):103-8. doi: 10.1080/00016350601083521.

  26. de Souza Rolim T, Fabri GM, Nitrini R, et al. Oral infections and orofacial pain in Alzheimer's disease: a case-control study. J Alzheimers Dis. 2014;38(4):823-9. doi: 10.3233/JAD-131283.

  27. Chalmers JM. Behavior management and communication strategies for dental professionals when caring for patients with dementia. Spec Care Dentist. 2000 Jul-Aug;20(4):147-54.

  28. Lee KH, Wu B, Plassman BL. Cognitive function and oral health-related quality of life in older adults. J Am Geriatr Soc. 2013 Sep;61(9):1602-7. doi: 10.1111/jgs.12402. Epub 2013 Aug 26.

  29. Locker D. Oral health and quality of life. Oral Health Prev Dent. 2004;2 Suppl 1:247-53.

  30. Litch CS, Liggett ML. Consent for dental therapy in severely ill patients. J Dent Educ. 1992 May;56(5):298-311.

  31. CDC. Arthritis. 2021 Oct 12. Accessed November 3, 2021.

  32. Arthritis Foundation. Arthritis by the numbers. Atlanta, GA. 2021. Accessed October 28, 2021.

  33. Barbour KE, Holmick CG, Boring MA, Brady TJ. Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation-United States, 2013-2015. Morb Mortal Wkly Rep. 2017 Mar 66(9);246-253.

  34. Bingham CO 3rd, Moni M. Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. Curr Opin Rheumatol. 2013 May;25(3):345-53. doi: 10.1097/BOR.0b013e32835fb8ec.

  35. Arthritis Foundation. Mouth Bacteria May Trigger RA. Atlanta, GA. 2021 Apr 14. Accessed October 28, 2021.

  36. Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017 Oct;13(10):606-620. doi: 10.1038/nrrheum.2017.132. Epub 2017 Aug 24.

  37. Zhao X, Liu Z, Shu D, et al. Association of Periodontitis with Rheumatoid Arthritis and the Effect of Non-Surgical Periodontal Treatment on Disease Activity in Patients with Rheumatoid Arthritis. Med Sci Monit. 2018 Aug 20;24:5802-5810. doi: 10.12659/MSM.909117.

  38. CDC. Chronic Obstructive Pulmonary Disease (COPD). 2021 Feb 22. Accessed October 28, 2021.

  39. NIH. National Heart Lung and Blood Institute. Asthma. Accessed October 28, 2021.

  40. NIH. National Heart Lung and Blood Institute. COPD. Accessed October 28, 2021.

  41. CDC. Asthma. 2021 Sept 16. Accessed October 28, 2021.

  42. AHRQ. Dental Recommendations for Preventing Complications in Patients with Chronic Conditions. Accessed October 28, 2021.

  43. Thomas MS, Parolia A, Kundabala M, et al. Asthma and oral health: a review. Aust Dent J. 2010 Jun;55(2):128-33. doi: 10.1111/j.1834-7819.2010.01226.x.

  44. NIMH. Depression. 2018 Feb. Accessed October 28, 2021.

  45. CDC. Mental Health. 2021 Jul 20. Accessed October 28, 2021.

  46. Datta D, Kumar RS, Narayanan AM, et al. Depression and Oral Health. International Journal of Current Research. 2018;10(3):66561-66564.

  47. Daly C. Oral and dental effects of antidepressants. Aust Prescr. 2016 Jun;39(3):84. doi: 10.18773/austprescr.2016.035. Epub 2016 Jun 1.

  48. CDC. Diabetes. 2021 Oct 15. Accessed October 28, 2021.

  49. Little JW, Miller CS, Rhodus NL. Dental Management of the Medically Compromised Patient, 9th Ed. St. Louis, MO. Elsevier. 2018.

  50. Lalla RV, D'Ambrosio JA. Dental management considerations for the patient with diabetes mellitus. J Am Dent Assoc. 2001 Oct;132(10):1425-32.

  51. NIH. National Institute of Diabetes and Digestive and Kidney Diseases. Low Blood Glucose (Hypoglycemia). 2021 Jul. Accessed October 28, 2021.

  52. Malamed SF. Medical emergencies in the dental office, 7th ed. St. Louis, MO. Elsevier. 2015.

  53. American Diabetes Association. Diabetes and Oral Health. Accessed October 28, 2021.

  54. Borgnakke WS, Ylöstalo PV, Taylor GW, et al. Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. J Periodontol. 2013 Apr;84(4 Suppl):S135-52. doi: 10.1902/jop.2013.1340013.

  55. CDC. Heart Disease. 2021 Jan 19. Accessed October 28, 2021.

  56. NIH. National Heart Lung and Blood Institute. Coronary Heart Disease. Accessed October 28, 2021.

  57. CDC. High Blood Pressure. 2021 Sept 27. Accessed October 28, 2021.

  58. American Heart Association. High Blood Pressure. Accessed October 28, 2021.

  59. Virani SS, Alonso A, Benjamin EJ, et al. Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. Circulation. 2020 Mar 3;141(9):e139-e596. doi: 10.1161/CIR.0000000000000757. Epub 2020 Jan 29. PMID: 31992061.

  60. National Multiple Sclerosis Society. What Is MS? Accessed October 28, 2021.

  61. National Multiple Sclerosis Society. Definition of MS. Accessed October 28, 2021.

  62. National Multiple Sclerosis Society. Symptoms & Diagnosis. Accessed October 28, 2021.

  63. American Academy of Neurology. Emotional disorders in people with Multiple Sclerosis. Accessed October 28, 2021.

  64. Wynn RL, Meiller TF, Crossley HL. Drug information handbook for dentistry, 19th Ed. Hudson, OH. Lexcomp, 2013.

  65. Paty DW, Ebers GC. Multiple Sclerosis, 3rd ed. Philadelphia, PA. FA David. 1998.

  66. 66. Pilitsis J, Khazen O. Trigeminal Neuralgia. American Association of Neurological Surgeons. Accessed October 28, 2021.

  67. Hilas O, Patel PN, Lam S. Disease modifying agents for multiple sclerosis. Open Neurol J. 2010 May 26;4:15-24. doi: 10.2174/1874205X01004010015.

  68. van der Mei IA, Simpson S Jr, Stankovich J, et al. Individual and joint action of environmental factors and risk of MS. Neurol Clin. 2011 May;29(2):233-55. doi: 10.1016/j.ncl.2010.12.007.

  69. Simon KC, Munger KL, Xing Yang, et al. Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis. Mult Scler. 2010 Feb;16(2):133-8. doi: 10.1177/1352458509355069. Epub 2009 Dec 9.

  70. Fontaine B, Barcellos LF. Evidence for a complex interaction between HLA-DRB1 and environmental factors in MS. Neurology. 2008 Jan 8;70(2):97-8. doi: 10.1212/01.wnl.0000296821.72466.d3.

  71. Wingerchuk DM. Environmental factors in multiple sclerosis: Epstein-Barr virus, vitamin D, and cigarette smoking. Mt Sinai J Med. 2011 Mar-Apr;78(2):221-30. doi: 10.1002/msj.20240.

  72. Ascherio A, Munger KL, Simon KC. Vitamin D and multiple sclerosis. Lancet Neurol. 2010 Jun;9(6):599-612. doi: 10.1016/S1474-4422(10)70086-7.

  73. Hernán MA, Jick SS, Logroscino G, et al. Cigarette smoking and the progression of multiple sclerosis. Brain. 2005 Jun;128(Pt 6):1461-5. Epub 2005 Mar 9.

  74. Riise T, Nortvedt MW, Ascherio A. Smoking is a risk factor for multiple sclerosis. Neurology. 2003 Oct 28;61(8):1122-4.

  75. National Multiple Sclerosis Society. Dental Health: The Basic Facts. Accessed October 28, 2021.

  76. Parkinson's Foundation. What Is Parkinson's? Accessed October 28, 2021.

  77. Parkinson's Foundation. Causes & Statistics Accessed October 28, 2021.

  78. Golbe LI, Mark MH, Sage JI. Parkinson's Disease Handbook. A guide for patients and their families. New Brunswick, New Jersey. The American Parkinson Disease Association, Inc., 2014. Accessed October 28, 2021.

  79. NIH. National Institute on Aging. Parkinson's Disease. 2017 May 16. Accessed October 28, 2021.

  80. American Parkinson Disease Association. Basic Information on Parkinson’s Disease: How We Can Help. Accessed October 28, 2021.

  81. Friedlander AH, Mahler M, Norman KM, et al. Parkinson disease: systemic and orofacial manifestations, medical and dental management. J Am Dent Assoc. 2009 Jun;140(6):658-69.

  82. Wirdefeldt K, Adami HO, Cole P, et al. Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol. 2011 Jun;26 Suppl 1:S1-58. doi: 10.1007/s10654-011-9581-6. Epub 2011 May 28.

  83. Schapira AH. Etiology of Parkinson's disease. Neurology. 2006 May 23;66(10 Suppl 4):S10-23.

  84. Martin I, Dawson VL, Dawson TM. Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet. 2011;12:301-25. doi: 10.1146/annurev-genom-082410-101440.

  85. Singleton AB, Farrer MJ, Bonifati V. The genetics of Parkinson's disease: progress and therapeutic implications. Mov Disord. 2013 Jan;28(1):14-23. doi: 10.1002/mds.25249.

  86. Jafari S, Etminan M, Aminzadeh F, et al. Head injury and risk of Parkinson disease: a systematic review and meta-analysis. Mov Disord. 2013 Aug;28(9):1222-9. doi: 10.1002/mds.25458. Epub 2013 Apr 22.

  87. American Parkinson Disease Association. What Is Early Onset Parkinson’s Disease? Accessed October 28, 2021.

  88. Parkinson's Foundation. Dental Health. Accessed October 28, 2021.

  89. Huber MA. Parkinson's disease and oral health. Educational supplement #7. Staten Island, NY. The American Parkinson Disease Association, Inc., 2007. Accessed October 28, 2021.

  90. Parkinson's Foundation. Understanding Parkinson's. Accessed October 28, 2021.

  91. Persson M, Osterberg T, Granérus AK, et al. Influence of Parkinson's disease on oral health. Acta Odontol Scand. 1992 Feb;50(1):37-42.

  92. Dirks SJ, Paunovich ED, Terezhalmy GT, et al. The patient with Parkinson's disease. Quintessence Int. 2003 May;34(5):379-93.

  93. Elbaz A, Moisan F. Update in the epidemiology of Parkinson's disease. Curr Opin Neurol. 2008 Aug;21(4):454-60. doi: 10.1097/WCO.0b013e3283050461.

  94. Hanaoka A, Kashihara K. Increased frequencies of caries, periodontal disease and tooth loss in patients with Parkinson's disease. J Clin Neurosci. 2009 Oct;16(10):1279-82. doi: 10.1016/j.jocn.2008.12.027. Epub 2009 Jun 30.

  95. Schwarz J, Heimhilger E, Storch A. Increased periodontal pathology in Parkinson's disease. J Neurol. 2006 May;253(5):608-11. Epub 2006 Mar 6. doi: 10.1007/s00415-006-0068-4.

  96. Müller T, Palluch R, Jackowski J. Caries and periodontal disease in patients with Parkinson's disease. Spec Care Dentist. 2011 Sep-Oct;31(5):178-81. doi: 10.1111/j.1754-4505.2011.00205.x.

  97. Bakke M, Larsen SL, Lautrup C, et al. Orofacial function and oral health in patients with Parkinson's disease. Eur J Oral Sci. 2011 Feb;119(1):27-32. doi: 10.1111/j.1600-0722.2010.00802.x.

  98. Nakayama Y, Washio M, Mori M. Oral health conditions in patients with Parkinson's disease. J Epidemiol. 2004 Sep;14(5):143-50.

  99. CDC. Stroke Signs and Symptoms. 20 Aug 28. Accessed October 28, 2021.

  100. CDC. National Diabetes Statistics. Accessed October 28, 2021.

  101. Kreiner M, Okeson J, Tanco V, Waldenström A, Isberg A. Orofacial Pain and Toothache as the Sole Symptom of an Acute Myocardial Infarction Entails a Major Risk of Misdiagnosis and Death. J Oral Facial Pain Headache. 2020 Winter;34(1):53–60. doi: 10.11607/ofph.2480. Epub 2019 Aug 27. PMID: 31465031.

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