Reference: M. Klukowska,* D. Ramsey,* C. Combs,* U. Rattanaudompol,* C. Haven,* D. McClenathan,* N. Ramji,* J. Milleman,+ K. Milleman.+ *Procter & Gamble, Cincinnati, OH, USA; +Salus Research Inc., Ft. Wayne, IN, USA.
Gingivitis is a common condition resulting in gingival bleeding and inflammation. Randomized controlled clinical trials show stabilized stannous fluoride dentifrice reduces gingivitis and plaque,1-4 the primary causative agent of gingivitis. Recent learnings show the gingival health benefits of stabilized stannous fluoride dentifrice are due in part to its effect on plaque virulence.5-7 Specifically, stannous fluoride binds to bacterial endotoxins in the gingival sulcus that trigger the inflammatory process, resulting in less toxic plaque and decreased inflammation and bleeding. Findings from this clinical trial provide further evidence that stannous fluoride penetrates subgingivally, reaching sites up to 4mm, and is retained at significant levels for 12 hours. Based on these findings, dental professionals should consider recommending a stabilized stannous fluoride dentifrice, like Crest Gum Detoxify, to treat and prevent gingivitis.
To evaluate stannous fluoride penetration and retention in GCF.
1. Mankodi S et al. J Clin Periodontol 2005;32:75-80. 2. Mallatt M et al. J Clin Periodontol 2007;34(9):762-7. 3. Archila L et al. J Periodontol 004;75(12):1592-1599. 4. He T et al. Am J Dent 2013;26:175-179. 5. Klukowska M et al. J Clin Dent 2017;28:16–26. 6. Haught C et al. Am J Dent 2016;29:328-332. 7. Haught C et al. J Clin Dent 2016;27:84–89.