These allergic reactions are systemic or localized, as in allergic dermatitis (e.g., hives, wheal and erythema reactions). The reaction is the result of an antigen cross-linking with membrane-bound IgE antibody of a mast cell or basophil. Histamine, serotonin, bradykinin, and lipid mediators (e.g., platelet activating factor, prostaglandins, and leukotrienes) are released during the anaphylactic reaction. These released substances have the potential to cause tissue damage.
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