Numerous 6-month clinical studies have shown statistically significant reductions in plaque and gingivitis for therapeutic CPC rinses relative to negative controls.10,20,21 Reductions ranged from 15% to 24% for gingivitis, 27% to 67% for bleeding, and 16% to 28% for plaque. Other extended use research has shown parity benefits to a positive control rinse.22,23
CPC’s safety has been well-documented.10,20-23 A small percent of patients may experience temporary taste alteration and/or transient staining as documented with any effective antimicrobial rinse.17 These side effects are usually observed more frequently from the use of prescription rinses (e.g., chlorhexidine) and occur less often in the over-the-counter formulations. With the 0.07% CPC rinse, (Crest® PRO-HEALTH™ Mouthwash) user acceptability was favorable along with a high patient compliance.24 This CPC therapeutic mouthrinse has further demonstrated excellent bioavailability success with bacterial cidal activity and antibacterial retention.25
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