Although ACP is currently not indicated as “strong” in the evidence-based literature, ACP has anticariogenic properties to promote the remineralization of enamel and cementum, as well as balancing the pH of saliva and reducing dentinal sensitivity. Regular application of ACP with fluoride increases levels of calcium and phosphate levels in biofilm and tooth structure. In fact, an addition of 2% ACP (i.e., Recaldent) to as little as 450 ppm fluoride can significantly increase the incorporation of fluoride ions into biofilm and co-localize calcium and phosphate ions with fluoride ions at the tooth surface. An adjunct treatment of ACP and a 1,100 ppm fluoridated dentifrice (toothpaste) can decrease bacteria and increase mineralization. Patients who benefit from ACP include conditions such as orthodontic, white spots, tooth whitening, oncology, hypersensitivity, high caries risk, xerostomia, and acid erosion due to sodas and other drinks. Calcium phosphate with fluoride can be added to teeth with various applicators. Custom mouthguards can also be used for longer application times.