Finding relevant evidence to answer clinical questions requires conducting a focused search of the peer-reviewed professional literature. To assist professionals in keeping up with the literature and in making it possible to quickly find needed information without leaving your location, online access to MEDLINE, the premier scientific database provided by the National Library of Medicine, is available at no cost through PubMed. The purpose of this course is to outline the steps involved in conducting a PubMed search using both the traditional comprehensive PubMed search mechanism, including the MeSH database, and the PubMed Clinical Queries feature to answer clinical questions. Case scenarios will demonstrate the application of the skills involved. To gain hands-on experience learning the skills, open a second window in your browser and complete each step as you read about it in the course.