With an ever-increasing elderly edentulous population, the dental profession is tasked to become more proficient in providing complete denture therapy, even in the face of significant residual ridge resorption. Once optimal complete denture fabrication has been achieved, the prescription of conservative and appropriate denture adhesive application can substantially aid prosthesis retention and stability, as well as facilitate patient psychological well-being. This course presents epidemiologic information detailing this needy patient population, the biomechanical phenomena of complete denture stability and retention, and the prescription and management of denture adhesive to supplement stability and retention in well-fabricated complete dentures.