Fluoride is an effective therapeutic and preventive agent for dental caries. The mineral alters the caries process by interfering with the dynamic of lesion development by enhancing remineralization, reducing demineralization, and inhibiting bacteria. While there are many forms of fluoride delivery, the incorporation of fluoride in a dentifrice has proven to be one of the most effective prevention and intervention strategies for dental caries. It should be noted that although fluoride therapy is important for caries control, it does not always stop caries development and progression. The tried-and-true public health recommendations of proper oral hygiene, such as brushing teeth at least twice a day, flossing to clean in between teeth, and cutting back on dietary sugar intake, continue to be very important in fighting caries.