These contain higher concentrations of fluoride than products sold over the counter for home use. They typically contain 5,000 ppm to 12,300 ppm and are applied only in the dental office. They are generally recommended for use twice yearly, although in severe cases, they may be applied more frequently. Significant reductions in dental caries—as much as 41%—have been seen when applied in this way.21 However, no benefit has been seen with the use of single applications or infrequent applications.
