Adjuvant Drugs to Enhance the Efficacy of Analgesics

Adjuvant drugs enhance the efficacy of analgesics or have analgesic activity of their own.55 Caffeine in doses greater than 100 mg enhances the analgesic effect of NSAIDs and APAP. Hydroxyzine, a first generation antihistamine, in doses of 25 to 50 mg enhances the analgesic effect of opioids and reduces the incidence of opioid-induced nausea and vomiting. Corticosteroids, through their phospholipase-inhibitory effects, enhance analgesia in patients with pain of inflammatory origin.