Adjuvant drugs enhance the efficacy of analgesics or have analgesic activity of their own.55 Caffeine in doses greater than 100 mg enhances the analgesic effect of NSAIDs and APAP. Hydroxyzine, a first generation antihistamine, in doses of 25 to 50 mg enhances the analgesic effect of opioids and reduces the incidence of opioid-induced nausea and vomiting. Corticosteroids, through their phospholipase-inhibitory effects, enhance analgesia in patients with pain of inflammatory origin.
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