Mild-to-moderate Odontogenic Pain

Ibuprofen, 200 mg, is somewhat more effective than naproxen sodium, 220 mg, and both are more effective than APAP, 650 mg (Table 2).36-40 Consequently, over-the-counter NSAIDs are the drugs of choice for the treatment of mild-to-moderate odontogenic pain. Since APAP has no significant anti-inflammatory activity, in the treatment of odontogenic pain APAP should only be considered as an alternative analgesic, i.e., when NSAIDs are contraindicated.

Table 2. Over-the-counter Analgesics for Mild-to-moderate Odontogenic Pain.

DrugUsual oral single dose in milligramsDosingMaximum daily dose in milligrams
Ibuprofen (generic, Motrin)200q4h1,200
400q6h
Naproxen sodium
(generic, Aleve)
220q6h1,100
Acetaminophen (generic, Tylenol)650q4h3,900