Mild-to-moderate Odontogenic Pain

Ibuprofen, 200 mg, is somewhat more effective than naproxen sodium, 220 mg, and both are more effective than APAP, 650 mg (Table 2).36-40 Consequently, over-the-counter NSAIDs are the drugs of choice for the treatment of mild-to-moderate odontogenic pain. Since APAP has no significant anti-inflammatory activity, in the treatment of odontogenic pain APAP should only be considered as an alternative analgesic, i.e., when NSAIDs are contraindicated.

Table 2. Over-the-counter Analgesics for Mild-to-moderate Odontogenic Pain.

Drug Usual oral single dose in milligrams Dosing Maximum daily dose in milligrams
Ibuprofen (generic, Motrin) 200 q4h 1,200
400 q6h
Naproxen sodium
(generic, Aleve)
220 q6h 1,100
Acetaminophen (generic, Tylenol) 650 q4h 3,900