Analgesics are specific inhibitors of pain pathways and include N-acetyl-p-aminophenol (APAP) or acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), opioid-receptor agonists, and opioid-receptor agonist/norepinephrine and serotonin reuptake inhibitors. Since the quintessential requisite for odontogenic pain is tissue trauma and inflammation, the optimal analgesic regimen should include an agent that suppresses pain and reduces inflammation, i.e., a disease-modifying analgesic.
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