A genetic disorder characterized by IL-1 gene polymorphism has been suggested as a risk factor for peri-implantitis.37 However, based on a systematic review of 27 relevant articles, no definitive conclusion can be drawn.38 In contradistinction, chronic inflammatory diseases, such as rheumatoid arthritis, do appear to increase the risk of peri-implantitis. A determination of the odds ratios through meta-analytic studies and systematic reviews is currently under way.39
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