Women are more likely to be diagnosed with AD, and their cognitive ability deteriorates at a much quicker rate, than their male counterparts.14,15 The 2010 U.S. Census revealed women account for nearly two-thirds of Americans diagnosed with AD.13 The biological mechanisms surrounding AD differences between the two genders are unknown. One possible explanation is that women simply live longer than men.16 The longer lifespan of women combined with the risk factor of age makes this rationalization plausible. Another conceivable explanation is the interaction of estrogen with the APOE‑e4 gene.17 The variance is also thought to be associated with biological variations, genetic variations, and life experiences.18 More research is needed to fully explain this disparity.
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