An exposure that might place HCP at risk for HAIs with bloodborne pathogens (i.e., infection with hepatitis B, hepatitis C, or human immunodeficiency viruses) is defined as a (1) percutaneous injury (e.g., needlesticks or cuts with sharp objects), (2) direct contact of ocular, nasal, or oral mucous membranes, or (3) direct contact of nonintact skin (e.g., dermatitis, or chapped or abraded skin) with blood and OPIM.4
Percutaneous wounds and nonintact skin that have been in contact with blood or OPIM should be washed with soap and water; mucous membranes should be flushed with water.5 Using antiseptics (e.g., chlorhexidine) for wound care or expressing fluid by squeezing the wound have not been shown to reduce the risk for infection. Injecting antiseptics or disinfectants into the wound and the application of caustic agents (e.g., bleach) is not recommended.
PEP intended to prevent HAIs is most effective when administered as soon after an exposure as possible (ideally within hours). Consequently, immediately after wound care, the exposure must be reported to the Office Infection Control Officer and the circumstances of the incident documented in accordance with all federal and state mandates.1,2,4 The report must include the date and time of exposure and details of the event (Box 1).
Following an exposure to blood and OPIM, the potential to transmit HBV, HCV, and HIV will depend on the type of body fluid involved and the route and severity of the exposure.4 Exposures to blood and OPIM through percutaneous injuries (i.e., needlesticks or other penetrating sharps-related events) or through direct contact with mucous membrane are situations that pose the greatest risk of bloodborne pathogen transmission in oral healthcare settings.
Exposure to a blood-filled hollow needle or visibly bloody instruments and other medical/dental devices suggests a higher risk than exposure to a needle that was used for administering an injection, e.g., a local anesthetic. Skin exposure to blood and OPIM, when the integrity of the skin is compromised (e.g., dermatitis, abrasion, or open wound), may potentially result in a healthcare-associated infection.
If the exposure incident was related to a human bite, possible exposure of both the person bitten and the person who inflicted the bite must be considered, especially if the bite resulted in bleeding. In addition, any direct contact (i.e., personal protective equipment was not used or was ineffective in protecting skin or mucous membranes) with concentrated HBV, HCV, or HIV in a research laboratory is considered a significant exposure incident.
The next step in data collection relates to the exposure source. The person whose blood or OPIM is the source of an occupational exposure should be evaluated for HBV, HCV, and HIV infection (Box 2). Information already available in the chart of the source person at the time of exposure (e.g., medical history and/or laboratory test results) or other information obtained from the source person might provide clues to potential infection with a bloodborne pathogen.
If the infectious status of the source person is unknown, he/she should be informed of the incident and after obtaining informed consent (in accordance with applicable state and local laws) should be tested for serologic evidence of HBV, HCV, and HIV infection. A source person determined to be infected with HBV, HCV, or HIV should be referred for medical treatment and counseling. Confidentiality of the source person must be maintained at all times.
If the source of blood or OPIM is unknown, information about where and under what circumstances the exposure occurred should be assessed. An important consideration is the prevalence of HBV, HCV, or HIV in the population from which the contaminated source material is derived. An exposure related to a community where injection-drug use is prevalent would present a higher risk for transmission than one related to a nursing home for the elderly.
Ideally, within hours of exposure to a bloodborne pathogen, exposed HCP should undergo postexposure evaluation by an expert consultant (a physician knowledgeable about occupational transmission and one who can deal with the many concerns of an exposed person). Exposed HCP should present for the evaluation with (1) the incident report, (2) all available information about the source person, and (3) his/her OSHA-mandated medical record maintained by the employer (Box 3).1-3