The widespread and ever increasing use of antibacterial agents contributes to the development of antibacterial drug-resistance.102,107,131-143 Unless healthcare providers change their practices, many currently available antibacterial agents may become ineffective. When antibacterial agents are used appropriately to treat complicated odontogenic infections or to prevent infections in high-risk patients, clinicians must accept the ecological consequences of antibacterial chemotherapy. However, when other therapeutic means are available, antibacterial agents should not be routinely prescribed to treat or to prevent infections.
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