The research focus on the role of periodontal and systemic diseases has somewhat overshadowed consideration of other oral conditions and their possible effects on wellbeing. Caries is also a disease caused through the intervention of microorganisms and can also lead to inflammation in the form of apical periodontitis. However, the resulting impact on general health tends to be acute with better defined treatment protocols. Having said that, serious conditions such as Ludwig’s angina and septicaemias do follow in some instances. Oral cancers and pre-cancers also have a direct bearing on general health and need to be factored in to the care and treatment of dental patients.