While genitourinary infections generally garner the most attention with regards to risk for preterm birth, other distant infections have also been associated with premature delivery, including pyelonephritis, appendicitis, pneumonia, and periodontal disease.36,72,73 Periodontal disease has been associated with prematurity in several different patient populations with odds ratios (OR) ranging from 5.28 to 7.9, depending upon the level of prematurity and severity of periodontitis.27,73 While some interventional studies have demonstrated a benefit to prematurity rates with treatment of periodontitis,29,74-76 others have not demonstrated a notable benefit from periodontal treatment during pregnancy.30,77,78
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