Anaphylaxis (Table 10) is a Type I hypersensitivity reaction. Initial exposure to an allergen results in antigen-specific antibody production dominated by the immunoglobulin E (IgE) isotype. Following re-exposure, IgE antibodies bind to mast cells and basophils associated with mucosal and epithelial tissues. The simultaneous binding of an antigen to adjacent IgE molecules fixed to Fc receptors triggers degranulation of mast cells and basophils resulting in the release of histamine, leukotrienes, prostaglandins, chemokines, enzymes and cytokines in target tissues.
Prevention:
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Signs and symptoms:
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Emergency response:
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Nota bene:
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