Saliva-based biomarkers for pre-malignant and malignant lesions include proteins, nucleic acids, vitamins, ions, genomic and proteomic targets such as enzymes, growth factors, cytokines, metalloproteinases, endothelin, cytokeratin, mRNA, DNA aberrations, and telomerase.40-42 MMPs have been studied as possible cancer biomarkers and have been found to be linked to tumor invasion and metastasis.43
Other biomarkers include salivary IL-1β, and IL-8, methylation markers, actin, myosin and microRNAs (a small non-coding RNA molecule that regulates gene expression).44,45 The only currently available point-of-care technology to identify patients at risk of oral cancer is OralRisk® HPV (OralDNA® Labs, Eden Prairie, MN). It identifies biomarkers for oral human papilloma viruses, several strains of which are known to be associated with oral cancer.46
Your session is about to expire. Do you want to continue logged in?