Adverse Drug Reactions - Part I
Drug-disease Interactions

Cardiac diseases can often result in reduced metabolic activity in general because of poor hepatic and renal perfusion.⁷ Hepatic dysfunction can affect drug metabolism and biliary excretion.⁷ Renal insufficiency can be expected to impair renal drug metabolism and clearance.⁷ Uncontrolled hypothyroidism decreases the rate of drug metabolism and increases sensitivity to CNS depressants; and uncontrolled hyperthyroidism can increase the rate of drug metabolism and increases sensitivity to CNS stimulants.⁷