The diagnosis of ADRs is highly subjective and imprecise. Complaints such as fatigue, inability to concentrate, and excessive sleepiness have been reported by healthy individuals not taking medications. It is also well known that patients receiving a placebo report ADRs. However, drugs as disease and symptom producing agents should always be considered in the formulation of a differential diagnosis and the following step-wise process can be helpful in assessing possible drug-related adverse reactions:
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