Adverse Drug Reactions - Part II
Primary Oncogenesis-related ADRs

In general, drugs that cause direct damage to DNA and/or that interfere with DNA repair are avoided in clinical practice. However, DNA damage and/or interference with DNA repair is the specific intent of cytotoxic alkylating agents used to treat neoplasia and such drugs can cause acute myelocytic leukemia.¹ Tamoxifen, an estrogen receptor antagonist used to treat estrogen-sensitive breast cancer, acting as a partial agonist at estrogen receptors in the uterus can cause endometrial carcinoma.¹