Viruses are obligate intracellular parasites called virions and consist of RNA or DNA genomes (Table 4).9,10 The viral genome is surrounded by a virus-encoded protein shell capsid. In some cases, the capsid is surrounded by an envelope, a lipid bilayer membrane that contains additional virus-encoded proteins. With some variations, all virions have the same general viral life cycle and each stage is a potential target for pharmacological intervention (Figure 8).10
|Influenza A and B||Influenza|
|Respiratory syncytial virus (RSV)||Upper respiratory tract infection|
|Human immunodeficiency virus 1 and 2 (HIV‑1 and HIV‑2)||AIDS|
|Hepatitis C virus (HCV)||Hepatitis C infection|
|Hepatitis B virus (HBV)||Hepatitis B infection|
|Herpes simplex virus 1 and 2 (HSV‑1 and HSV‑2)||Primary herpetic gingivostomatitis
Herpes-associated erythema multiforme
Recurrent herpetic infections
|Varicella-zoster virus (VZV)||Chickenpox and herpes zoster infections|
|Human cytomegalovirus (HCMV)||Retinitis, esophagitis, and colitis|
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