Predicated on their mechanisms of action, 38 of the Top 300 Drugs of 2017 dispensed by U.S. community pharmacies are prescribed for the treatment of respiratory, GI, and GU disorders. Respiratory, GI, and GU abnormalities may be associated with mild to potentially life-threatening complications and may interfere with the quality of life of patients. Underling medical pathoses, their treatment, and quality of life issues may affect the clinical process in dentistry.