Botulinum toxin Type A (BTX) (OnabotulinumtoxinA - trade name Botox®) is well-known for its use for cosmetic procedures, such as smoothing frown lines and other facial wrinkles. However, BTX also presents therapeutic as well as cosmetic uses in dentistry. The dental clinician should be aware of these uses in order to educate the patient and present a more complete treatment plan. This course will define BTX, give a brief history, discuss general and dental uses, explore the mechanism of action, list side effects, consider administration guidelines, suggest patient management techniques and provide additional resources.