Proposed Mechanisms of Interaction between Periodontal Disease and Dementia

Periodontitis has been linked to cognitive impairment and dementia after controlling for confounding factors such as age, sex, and educational attainment.4,15,17,64-67 Disease progression in periodontal disease is associated with dysbiosis and elevated chronic inflammation, and dementia and Alzheimer’s Disease have been linked to periodontal disease through both inflammatory and bacterial mechanisms.17,24,25,68-73 Periodontal disease has also been linked to increased systemic and neurological markers of Alzheimer’s disease.17,74,75