LAs’ receptors on the voltage-gated sodium channels are integral membrane proteins. Predictably, the primary determinant of a LA’s duration of action is its protein-binding capacity (Table 1). LAs with high protein-binding capacity bind more tightly to and dissociate more slowly from their receptor sites and, therefore, have a longer duration of action (Table 4).2-13 Other factors affecting the duration of action of LAs include their lipid solubility, vascularity at the injection site, the presence of a vasoconstrictor in the formulation, and dosing.
|Infiltration: Pulpal Anesthesia||Nerve Block: Pulpal Anesthesia||Soft Tissue Anesthesia|
|Lidocaine 2 %, plain||5 min.||—||120 min.|
|Mepivacaine 3 %, plain||20-30 min.||45-65 min.||120-180 min.|
|Prilocaine 4 %, plain||10-15 min.||45-65 min.||180-240 min.|
|Lidocaine 2 %, w/epi.||55-70 min.||80-90 min.||180-300 min.|
|Mepivacaine 2 %, w/lev.||40-60 min.||60-90 min.||180-300 min.|
|Articaine 4 %, w/epi.||60-75 min.||120 min.||180-300 min.|
|Prilocaine 4 %, w. epi.||30-45 min.||50-70 min.||180-360 min.|
|Bupivacaine 0.5 %,||7 hrs.||47 hrs.||12 hrs.|
Your session is about to expire. Do you want to continue logged in?
WARNING! You did not finish creating your certificate. Please click CONTINUE below to return to your previous page to complete the process. Failure to complete ALL the steps will result in a loss of this test score, and you will not receive credit for this course.