Idiosyncratic Reactions

Methemoglobinemia is an uncommon idiosyncratic reaction most notably to prilocaine and topical benzocaine.6‑10,20,21,34‑38 Their metabolites bind to hemoglobin and interfere with its oxygen-carrying capacity. Signs and symptoms usually appear 3 to 4 hours after exposure and may include cyanosis, fatigue, weakness, nausea, sedation, seizures, and coma. Young patients and those with congenital methemoglobinemia or glucose‑6‑phosphate deficiency are the most susceptible. chat Let's get started!