Local Anesthetic Agents in Dentistry
Local Anesthetic Agents and Pregnancy

The 2014 FDA amendment to regulations governing the content and format of labeling for human prescription drugs and biological products, which became effective on 30 June 2015, required the removal of the old pregnancy categories A, B, C, D, and X from all drug product labeling.³⁹ Information about LA-related risks to the fetus and recommendations about the use of LAs during pregnancy can now be found in the new “Pregnancy” subsection of specific package inserts.^6-10