The structural domain of LAs responsible for their lipophilicity is the aromatic group. The lipid solubility or partition coefficient of LAs determine their ability to pass through biological membranes and reach their sites of action.2-10 Therefore, the primary determinant of an agent’s potency is its partition coefficient. A LA with higher potency will require a lower dose to achieve the same degree of neuronal blockade as that achieved by an agent with lower potency (Table 2).
|Formulations||2%||2% or 3%||4%||4%||0.5%|
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