Design Principles for Oxidative Tooth Whitening – Factors Affecting Efficacy

Now that we have reviewed how and why teeth are colored and the mechanisms whereby these chromogens can be removed or decolorized, we are prepared to consider how innovators design oxidative, especially peroxide-based tooth whiteners. The design chemistry of effective formulations for tooth bleaching depends on many factors, including those listed here:

• Ingredients used in Oxidative Whitening

• Concentration of Ingredients Used in Oxidative Whitening

• Dose of Ingredients Used in Tooth Whitening

• Duration of Treatment – Retention of Ingredient (contact time)