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Caries Process, Prevention, and Management: The Agent

Course Number: 711

References / Additional Resources

  1. National Institute of Dental and Craniofacial Research. Dental Caries (Tooth Decay) in Children Age 2 to 11. Updated July 2018. Accessed March 25th, 2025.

  2. National Institute of Dental and Craniofacial Research. Dental Caries (Tooth Decay) in Adults (Ages 20 to 64). Accessed March 25th, 2025.

  3. Ribeiro AA, Paster BJ. Dental caries and their microbiomes in children: what do we do now? J Oral Microbiol. 2023 Apr 10;15(1):2198433. doi: 10.1080/20002297.2023.2198433. PMID: 37056224; PMCID: PMC10088930.

  4. Ribeiro AA, Azcarate-Peril MA, Cadenas MB, et al. The oral bacterial microbiome of occlusal surfaces in children and its association with diet and caries. PLoS One. 2017;12(7):e0180621. Published 2017 Jul 5. doi:10.1371/journal.pone.0180621

  5. Gerabek WE. The tooth-worm: historical aspects of a popular medical belief. Clin Oral Investig. 1999 Mar;3(1):1-6. doi: 10.1007/s007840050070.

  6. Newbrun E. Sugar and dental caries: a review of human studies. Science. 1982 Jul 30;217(4558):418-23. doi: 10.1126/science.7046052.

  7. Christen AG. Sumter Smith Arnim, DDS, PhD (1904-1990): a pioneer in preventive dentistry. J Dent Res. 1995 Oct;74(10):1630-5. doi: 10.1177/00220345950740100201.

  8. Ismail AI, Hasson H, Sohn W. Dental caries in the second millennium. J Dent Educ. 2001 Oct;65(10):953-959.

  9. Ripa LW. A half-century of community water fluoridation in the United States: review and commentary. J Public Health Dent. 1993 Winter;53(1):17-44. doi: 10.1111/j.1752-7325.1993.tb02666.x.

  10. American Dental Association. Fluoridation Facts 2018. Accessed March 25th, 2025.

  11. Filoche S, Wong L, Sissons CH. Oral biofilms: emerging concepts in microbial ecology. J Dent Res. 2010 Jan;89(1):8-18. doi: 10.1177/0022034509351812.

  12. Marsh PD, Martin M. Oral Microbiology, 6th ed. ENew York, NY. Elsevier. 2016.

  13. Ochiai K, Kurita-Ochiai T, Kamino Y, Ikeda T. Effect of co-aggregation on the pathogenicity of oral bacteria. J Med Microbiol. 1993 Sep;39(3):183-90. doi: 10.1099/00222615-39-3-183.

  14. Dewhirst FE, Chen T, Izard J et al (2010) The human oral microbiome. J Bacteriol 192:5002–5017

  15. Becker MR, Paster BJ, Leys EJ, et al. Molecular analysis of bacterial species associated with childhood caries. J Clin Microbiol. 2002 Mar;40(3):1001–1009. PMID: 11880430; PMCID: PMC120252. DOI:10. 1128/JCM.40.3.1001-1009.2002.

  16. van Houte J, Lopman J, Kent R. The final pH of bacteria comprising the predominant flora on sound and carious human root and enamel surfaces. J Dent Res. 1996 Apr;75(4):1008–1014. PMID: 8708129. DOI:10.1177/00220345960750040201.

  17. Johansson I, Witkowska E, Kaveh B, et al. The microbiome in populations with a low and high prevalence of caries. J Dent Res. 2016 Jan;95(1):80–86. Epub 2015 Oct 6. PMID: 26442950; PMCID: PMC4700664. DOI:10.1177/0022034515609554.

  18. da Costa Rosa T, de Almeida Neves A, Azcarate-Peril MA, et al. The bacterial microbiome and metabolome in caries progression and arrest. Journal of Oral Microbiology. 2021 Jun;13(1):1886748. DOI: 10.1080/20002297.2021.1886748. PMID: 34188775; PMCID: PMC8211139.

  19. Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994 Jul;8(2):263-71. doi: 10.1177/08959374940080022001.

  20. Kolenbrander PE, et al. Communication among oral bacteria. Microbiol Mol Biol Rev. 2002;66(3):486-505

  21. Simon-Soro A, Ren Z, Krom BP, Hoogenkamp MA, Cabello-Yeves PJ, Daniel SG, Bittinger K, Tomas I, Koo H, Mira A. Polymicrobial Aggregates in Human Saliva Build the Oral Biofilm. mBio. 2022 Feb 22;13(1):e0013122. doi: 10.1128/mbio.00131-22. Epub 2022 Feb 22. PMID: 35189700; PMCID: PMC8903893.

  22. Keijser BJ, Zaura E, Huse SM, van der Vossen JM, Schuren FH, Montijn RC, ten Cate JM, Crielaard W. Pyrosequencing analysis of the oral microflora of healthy adults. J Dent Res. 2008 Nov;87(11):1016-20. doi: 10.1177/154405910808701104.

  23. Touger-Decker R, van Loveren C. Sugars and dental caries. Am J Clin Nutr. 2003 Oct;78(4):881S-892S. doi: 10.1093/ajcn/78.4.881S.

  24. Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology (Reading). 2003 Feb;149(Pt 2):279-294. doi: 10.1099/mic.0.26082-0.

  25. Hicks J, Garcia-Godoy F, Flaitz C. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent. 2003 Fall;28(1):47-52. doi: 10.17796/jcpd.28.1.yg6m443046k50u20.

Additional Resources


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