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The Dental Professional’s Role in the Prevention of Antibiotic Resistance and Adverse Antibiotic Reactions

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References / Additional Resources

  1. Kelekar U, Naavaal S. Dental visits and associated emergency department-charges in the United States: Nationwide Emergency Department Sample, 2014. J Am Dent Assoc. 2019;150(4):305–312.e1. doi:10.1016/j.adaj.2018.11.021.

  2. Durkin MJ, Hsueh K, Sallah YH, et al. An evaluation of dental antibiotic prescribing practices in the United States. J Am Dent Assoc. 2017;148(12):878–886.e1. doi:10.1016/j.adaj.2017.07.019.

  3. Gross AE, Hanna D, Rowan SA, Bleasdale SC, Suda KJ. Successful Implementation of an Antibiotic Stewardship Program in an Academic Dental Practice. Open Forum Infect Dis. 2019;6(3):ofz067. Published 2019 Feb 13. doi:10.1093/ofid/ofz067.

  4. Suda KJ, Henschel H, Patel U, Fitzpatrick MA, Evans CT. Use of Antibiotic Prophylaxis for Tooth Extractions, Dental Implants, and Periodontal Surgical Procedures. Open Forum Infect Dis. 2017;5(1):ofx250. Published 2017 Nov 15. doi:10.1093/ofid/ofx250.

  5. Löffler C, Böhmer F. The effect of interventions aiming to optimise the prescription of antibiotics in dental care-A systematic review. PLoS One. 2017;12(11):e0188061. Published 2017 Nov 14. doi:10.1371/journal.pone.0188061.

  6. CDC. Antibiotic/Antimicrobial Resistance (AR/AMR). About Antibiotic Resistance. Accessed April 10, 2020.

  7. Lockhart PB, Tampi MP, Abt E, et al. Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association. J Am Dent Assoc. 2019;150(11):906–921.e12. doi:10.1016/j.adaj.2019.08.020.

  8. Swann JP. The search for synthetic penicillin during World War II. Br J Hist Sci. 1983;16(53 Pt 2):154–190. doi:10.1017/s0007087400026789.

  9. Health Canada. Health Policy Research. Antimicrobial Resistance: Keeping It In the Box! Accessed April 10, 2020.

  10. Beringer PM, Wong-Beringer A, Rho JP. Economic aspects of antibacterial adverse effects. Pharmacoeconomics. 1998;13(1 Pt 1):35–49. doi:10.2165/00019053-199813010-00004.

  11. Thornhill MH, Dayer MJ, Prendergast B, Baddour LM, Jones S, Lockhart PB. Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis. J Antimicrob Chemother. 2015;70(8):2382–2388. doi:10.1093/jac/dkv115.

  12. Leffler DA, Lamont JT. Clostridium difficile Infection. N Engl J Med. 2015;373(3):287–288. doi:10.1056/NEJMc1506004.

  13. WHO. Antimicrobial resistance. Global action plan on antimicrobial resistance. Accessed April 10, 2020.

  14. CDC. Antibiotic/Antimicrobial Resistance (AR/AMR). Biggest Threats and Data. 2019 AR Threats Report. Accessed April 10, 2020.

  15. CDC. Infographic: Actions for Healthcare Providers. Accessed April 10, 2020.

  16. American Association of Endodontists. Clinical Resources. Glossary of Endodontic Terms. Accessed April 10, 2020.

  17. CDC. Outpatient antibiotic prescriptions — United States, 2014. Accessed April 10, 2020.

  18. Centers for Disease Control and Prevention (CDC). Office-related antibiotic prescribing for persons aged ≤ 14 years--United States, 1993-1994 to 2007-2008. MMWR Morb Mortal Wkly Rep. 2011;60(34):1153–1156.

  19. Pichichero ME. Dynamics of antibiotic prescribing for children. JAMA. 2002;287(23):3133–3135. doi:10.1001/jama.287.23.3133.

  20. Shapiro DJ, Hicks LA, Pavia AT, Hersh AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09. J Antimicrob Chemother. 2014;69(1):234–240. doi:10.1093/jac/dkt301.

  21. Lockhart PB, Hanson NB, Ristic H, Menezes AR, Baddour L. Acceptance among and impact on dental practitioners and patients of American Heart Association recommendations for antibiotic prophylaxis. J Am Dent Assoc. 2013;144(9):1030–1035. doi:10.14219/jada.archive.2013.0230.

  22. WHO. Newsroom. Fact Sheets. Antimicrobial Resistance. 2018 Feb 15. Accessed April 10, 2020.

  23. CDC. Antibiotic/Antimicrobial Resistance (AR/AMR). Accessed April 10, 2020.

  24. Abraham EP, Chain E. An enzyme from bacteria able to destroy penicillin. 1940. Rev Infect Dis. 1988;10(4):677–678.

  25. CDC. U.S. National Action Plan for Combating Antibiotic-Resistant Bacteria (National Action Plan). 2015 Mar. Accessed April 10, 2020.

  26. CDC. U.S. National Action Plan for Combating Antibiotic-Resistant Bacteria. Summary. 2015 Mar. Accessed April 10, 2020.

  27. El-Sayed A. America Dissected: Superbugging Out. Podcast. Crooked. Accessed April 10, 2020.

  28. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study [published correction appears in Clin Infect Dis. 2004 Oct 1;39(7):1093] [published correction appears in Clin Infect Dis. 2005 Apr 1;40(7):1077]. Clin Infect Dis. 2004;39(3):309–317. doi:10.1086/421946.

  29. Jones M, Jernigan JA, Evans ME, Roselle GA, Hatfield KM, Samore MH. Vital Signs: Trends in Staphylococcus aureus Infections in Veterans Affairs Medical Centers - United States, 2005-2017. MMWR Morb Mortal Wkly Rep. 2019;68(9):220–224. Published 2019 Mar 8. doi:10.15585/mmwr.mm6809e2.

  30. David MZ, Glikman D, Crawford SE, et al. What is community-associated methicillin-resistant Staphylococcus aureus?. J Infect Dis. 2008;197(9):1235–1243. doi:10.1086/533502.

  31. Popovich KJ, Snitkin ES, Hota B, et al. Genomic and Epidemiological Evidence for Community Origins of Hospital-Onset Methicillin-Resistant Staphylococcus aureus Bloodstream Infections. J Infect Dis. 2017;215(11):1640–1647. doi:10.1093/infdis/jiw647.

  32. Cohen LA, Bonito AJ, Akin DR, et al. Toothache pain: a comparison of visits to physicians, emergency departments and dentists. J Am Dent Assoc. 2008;139(9):1205–1216. doi:10.14219/jada.archive.2008.0336.

  33. Shah AC, Leong KK, Lee MK, Allareddy V. Outcomes of hospitalizations attributed to periapical abscess from 2000 to 2008: a longitudinal trend analysis. J Endod. 2013;39(9):1104–1110. doi:10.1016/j.joen.2013.04.042.

  34. Stein K, Farmer J, Singhal S, Marra F, Sutherland S, Quiñonez C. The use and misuse of antibiotics in dentistry: A scoping review. J Am Dent Assoc. 2018;149(10):869–884.e5. doi:10.1016/j.adaj.2018.05.034.

  35. Newlands R, Duncan EM, Prior M, et al. Barriers and facilitators of evidence-based management of patients with bacterial infections among general dental practitioners: a theory-informed interview study. Implement Sci. 2016;11:11. Published 2016 Jan 29. doi:10.1186/s13012-016-0372-z.

  36. Dar-Odeh NS, Abu-Hammad OA, Al-Omiri MK, Khraisat AS, Shehabi AA. Antibiotic prescribing practices by dentists: a review. Ther Clin Risk Manag. 2010;6:301–306. Published 2010 Jul 21. doi:10.2147/tcrm.s9736.

  37. Marra F, George D, Chong M, Sutherland S, Patrick DM. Antibiotic prescribing by dentists has increased: Why?. J Am Dent Assoc. 2016;147(5):320–327. doi:10.1016/j.adaj.2015.12.014.

  38. CDC. Is it Really a Penicillin Allergy? Accessed April 10, 2020

  39. Blumenthal KG, Peter JG, Trubiano JA, Phillips EJ. Antibiotic allergy. Lancet. 2019;393(10167):183–198. doi:10.1016/S0140-6736(18)32218-9.

  40. Thornhill MH, Dayer MJ, Prendergast B, Baddour LM, Jones S, Lockhart PB. Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis. J Antimicrob Chemother. 2015;70(8):2382–2388. doi:10.1093/jac/dkv115.

  41. Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med. 2015;372(16):1539–1548. doi:10.1056/NEJMra1403772.

  42. Barlam TF, Cosgrove SE, Abbo LM, et al. Executive Summary: Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):1197–1202. doi:10.1093/cid/ciw217.

  43. Llewelyn MJ, Fitzpatrick JM, Darwin E, et al. The antibiotic course has had its day. BMJ. 2017;358:j3418. Published 2017 Jul 26. doi:10.1136/bmj.j3418.

  44. Durkin MJ, Feng Q, Warren K, et al. Assessment of inappropriate antibiotic prescribing among a large cohort of general dentists in the United States. J Am Dent Assoc. 2018;149(5):372–381.e1. doi:10.1016/j.adaj.2017.11.034.

  45. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group [published correction appears in Circulation. 2007 Oct 9;116(15):e376-7]. Circulation. 2007;116(15):1736–1754. doi:10.1161/CIRCULATIONAHA.106.183095.

  46. Watters W 3rd, Rethman MP, Hanson NB, et al. Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures. J Am Acad Orthop Surg. 2013;21(3):180–189. doi:10.5435/JAAOS-21-03-180.

  47. Sollecito TP, Abt E, Lockhart PB, et al. The use of prophylactic antibiotics prior to dental procedures in patients with prosthetic joints: Evidence-based clinical practice guideline for dental practitioners--a report of the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2015;146(1):11–16.e8. doi:10.1016/j.adaj.2014.11.012.

  48. Duval X, Alla F, Hoen B, et al. Estimated risk of endocarditis in adults with predisposing cardiac conditions undergoing dental procedures with or without antibiotic prophylaxis. Clin Infect Dis. 2006;42(12):e102–e107. doi:10.1086/504385.

  49. Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with toothbrushing and dental extraction. Circulation. 2008;117(24):3118–3125. doi:10.1161/CIRCULATIONAHA.107.758524.

  50. Lockhart PB, Brennan MT, Thornhill M, et al. Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc. 2009;140(10):1238–1244. doi:10.14219/jada.archive.2009.0046.

  51. Tomás I, Diz P, Tobías A, Scully C, Donos N. Periodontal health status and bacteraemia from daily oral activities: systematic review/meta-analysis. J Clin Periodontol. 2012;39(3):213–228. doi:10.1111/j.1600-051X.2011.01784.x.

  52. Gynther GW, Köndell PA, Moberg LE, Heimdahl A. Dental implant installation without antibiotic prophylaxis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(5):509–511. doi:10.1016/s1079-2104(98)90281-5.

  53. Scottish Intercollegiate Guidelines Network (SIGN). Antibiotic Prophylaxis in Surgery A National Clinical Guideline. SIGN 104; SIGN: Edinburgh, Scotland, 2014. Accessed April 10, 2020.

  54. Martin MV, Kanatas AN, Hardy P. Antibiotic prophylaxis and third molar surgery. Br Dent J. 2005;198(6):327–330. doi:10.1038/sj.bdj.4812170.

  55. Singh Gill A, Morrissey H, Rahman A. A Systematic Review and Meta-Analysis Evaluating Antibiotic Prophylaxis in Dental Implants and Extraction Procedures. Medicina (Kaunas). 2018;54(6):95. Published 2018 Dec 1. doi:10.3390/medicina54060095.

  56. Greenstein G, Tarnow D. Effectiveness of Antibiotics to Reduce Early Implant Loss in Systemically Healthy Patients. Compend Contin Educ Dent. 2020;41(2):102–110.

  57. Suda KJ, Calip GS, Zhou J, et al. Assessment of the Appropriateness of Antibiotic Prescriptions for Infection Prophylaxis Before Dental Procedures, 2011 to 2015. JAMA Netw Open. 2019;2(5):e193909. Published 2019 May 3. doi:10.1001/jamanetworkopen.2019.3909.

  58. Diz Dios P, Tomás Carmona I, Limeres Posse J, Medina Henríquez J, Fernández Feijoo J, Alvarez Fernández M. Comparative efficacies of amoxicillin, clindamycin, and moxifloxacin in prevention of bacteremia following dental extractions. Antimicrob Agents Chemother. 2006;50(9):2996–3002. doi:10.1128/AAC.01550-05.

  59. Lacasa JM, Jiménez JA, Ferrás V, et al. Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg). Int J Oral Maxillofac Surg. 2007;36(4):321–327. doi:10.1016/j.ijom.2006.11.007.

  60. Kaczmarzyk T, Wichlinski J, Stypulkowska J, Zaleska M, Panas M, Woron J. Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery. Int J Oral Maxillofac Surg. 2007;36(5):417–422. doi:10.1016/j.ijom.2006.12.003.

  61. Sekhar CH, Narayanan V, Baig MF. Role of antimicrobials in third molar surgery: prospective, double blind,randomized, placebo-controlled clinical study. Br J Oral Maxillofac Surg. 2001;39(2):134–137. doi:10.1054/bjom.2000.0557.

  62. Esposito M, Grusovin MG, Worthington HV. Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications. Cochrane Database Syst Rev. 2013;2013(7):CD004152. Published 2013 Jul 31. doi:10.1002/14651858.CD004152.pub4.

  63. Rodríguez Sánchez F, Rodríguez Andrés C, Arteagoitia I. Which antibiotic regimen prevents implant failure or infection after dental implant surgery? A systematic review and meta-analysis. J Craniomaxillofac Surg. 2018;46(4):722–736. doi:10.1016/j.jcms.2018.02.004.

  64. Braun RS, Chambrone L, Khouly I. Prophylactic antibiotic regimens in dental implant failure: A systematic review and meta-analysis. J Am Dent Assoc. 2019;150(6):e61–e91. doi:10.1016/j.adaj.2018.10.015.

  65. Ata-Ali J, Ata-Ali F, Ata-Ali F. Do antibiotics decrease implant failure and postoperative infections? A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2014;43(1):68–74. doi:10.1016/j.ijom.2013.05.019.

  66. Chrcanovic BR, Albrektsson T, Wennerberg A. Prophylactic antibiotic regimen and dental implant failure: a meta-analysis. J Oral Rehabil. 2014;41(12):941–956. doi:10.1111/joor.12211.

  67. Lund B, Hultin M, Tranaeus S, Naimi-Akbar A, Klinge B. Complex systematic review - Perioperative antibiotics in conjunction with dental implant placement. Clin Oral Implants Res. 2015;26 Suppl 11:1–14. doi:10.1111/clr.12637.

  68. Wylie I; BDA. Oral Healthcare for older people: 2020 vision. Gerodontology. 2003;20(1):60–62.

  69. Machuca G, Nieves E, Sanchez AF, Machuca C, Bullon P. Descriptive study factors modifying the periodontal status of a population of people with a learning disability in Spain. J Disabil Oral Health 2007; 8:73-80. Accessed April 10, 2020.

  70. Tiller S, Wilson KI, Gallagher JE. Oral health status and dental service use of adults with learning disabilities living in residential institutions and in the community. Community Dent Health. 2001;18(3):167–171.

  71. Cocero N, Frascolino C, Berta GN, Carossa S. Is It Safe to Remove Teeth in Liver Transplant Patients Without Antibiotics? A Retrospective Study of 346 Patients. J Oral Maxillofac Surg. 2019;77(8):1557–1565. doi:10.1016/j.joms.2019.03.028.

  72. Spuller RL. The central indwelling venous catheter in the pediatric patient--dental treatment considerations. Spec Care Dentist. 1988;8(2):74–76. doi:10.1111/j.1754-4505.1988.tb00696.x.

  73. Al-Bazie SA, Bahatheq M, Al-Ghazi M, Al-Rajhi N, Ramalingam S. Antibiotic protocol for the prevention of osteoradionecrosis following dental extractions in irradiated head and neck cancer patients: A 10 years prospective study. J Cancer Res Ther. 2016;12(2):565–570. doi:10.4103/0973-1482.159090.

  74. Nabil S, Samman N. Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg. 2011;40(3):229–243. doi:10.1016/j.ijom.2010.10.005.

  75. Moreno-Drada JA, García-Perdomo HA. Effectiveness of Antimicrobial Prophylaxis in Preventing the Spread of Infection as a Result of Oral Procedures: A Systematic Review and Meta-Analysis. J Oral Maxillofac Surg. 2016;74(7):1313–1321. doi:10.1016/j.joms.2016.03.006.

  76. Cope AL, Chestnutt IG. Inappropriate prescribing of antibiotics in primary dental care: reasons and resolutions. Prim Dent J. 2014;3(4):33–37. doi:10.1308/205016814813877333.

  77. ADA. ACE Panel Report. Antibiotic Use in Endodontic Infections. 2019 Apr 01. Accessed April 10, 2020.

  78. McGow CJ. Prescribing antibiotics "just in case" must be tackled to slow rise in antibiotic resistance. BMJ. 2019;364:l553. Published 2019 Feb 6. doi:10.1136/bmj.l553.

  79. Cope AL, Francis NA, Wood F, Chestnutt IG. Antibiotic prescribing in UK general dental practice: a cross-sectional study. Community Dent Oral Epidemiol. 2016;44(2):145–153. doi:10.1111/cdoe.12199.

  80. Marra F, George D, Chong M, Sutherland S, Patrick DM. Antibiotic prescribing by dentists has increased: Why?. J Am Dent Assoc. 2016;147(5):320–327. doi:10.1016/j.adaj.2015.12.014.

  81. Elouafkaoui P, Young L, Newlands R, et al. An Audit and Feedback Intervention for Reducing Antibiotic Prescribing in General Dental Practice: The RAPiD Cluster Randomised Controlled Trial. PLoS Med. 2016;13(8):e1002115. Published 2016 Aug 30. doi:10.1371/journal.pmed.1002115.

  82. Palmer NA, Dailey YM, Martin MV. Can audit improve antibiotic prescribing in general dental practice?. Br Dent J. 2001;191(5):253–255. doi:10.1038/sj.bdj.4801156a.

  83. Navathe AS, Emanuel EJ. Physician Peer Comparisons as a Nonfinancial Strategy to Improve the Value of Care. JAMA. 2016;316(17):1759–1760. doi:10.1001/jama.2016.13739.

  84. Milani RV, Wilt JK, Entwisle J, Hand J, Cazabon P, Bohan JG. Reducing inappropriate outpatient antibiotic prescribing: normative comparison using unblinded provider reports. BMJ Open Qual. 2019;8(1):e000351. Published 2019 Feb 13. doi:10.1136/bmjoq-2018-000351.

  85. Ubel PA, Asch DA. Creating value in health by understanding and overcoming resistance to de-innovation. Health Aff (Millwood). 2015;34(2):239–244. doi:10.1377/hlthaff.2014.0983.

  86. Fleming-Dutra KE, Bartoces M, Roberts RM, Hicks LA. Characteristics of Primary Care Physicians Associated With High Outpatient Antibiotic Prescribing Volume. Open Forum Infect Dis. 2018;5(1):ofx279. Published 2018 Jan 5. doi:10.1093/ofid/ofx279.

  87. UK Department of Health. Review on Antimicrobial Resistance: Tacking drug-resistant infections globally. Final report and recommendations. Chaired by Jim O’Neill. May 2016. Accessed April 10, 2020.

  88. Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014;6:25–64. Published 2014 Aug 28. doi:10.4137/PMC.S14459.

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