Drug-disease Interactions

Cardiac diseases can often result in reduced metabolic activity in general because of poor hepatic and renal perfusion.¹³ Hepatic dysfunction can affect drug metabolism and biliary excretion.¹³ Renal insufficiency can be expected to impair renal drug metabolism and clearance.¹³ Uncontrolled hypothyroidism decreases the rate of drug metabolism and increases sensitivity to CNS depressants, while uncontrolled hyperthyroidism can increase the rate of drug metabolism and increases sensitivity to CNS stimulants.¹³