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Adverse Drug Reactions - Part I

Course Number: 536

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References / Additional Resources

  1. World Health Organization. World alliance for patient safety: WHO draft guidelines for adverse event reporting and learning systems: from information to action. 30 October 2005. Accessed October 10, 2025.

  2. U.S. Food and Drug Administration. Guideline for Industry. Clinical Safety Data Management: Definitions and Standards for Expedited Reporting March 1995. Accessed October 10, 2025.

  3. Insani WN, Whittlesea C, Alwafi H, et al. Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis. PLoS One. 2021 May 26;16(5):e0252161 doi: 10.1371/journal.pone.0252161.

  4. Valhe JL, Hutto DL, Postema M. Drug discovery and preclinical development. In: Golan DE, Armstrong EJ, Armstrong AW, eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 4th ed. Philadelphia, PA: Wolters Kluwer; 2017:919-932.

  5. Goldberg MA, Kuta AE. Clinical drug evaluation and regulatory approval. In: Golan DE, Armstrong EJ, Armstrong AW, eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 4th ed. Philadelphia, PA: Wolters Kluwer; 2017:933-945.

  6. Conner MW, Dorian-Conner C, Vaidya VS, et al. Drug toxicity. In: Golan DE, Armstrong EJ, Armstrong AW, eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 4th ed. Philadelphia, PA: Wolters Kluwer; 2017:70-86.

  7. Raffa RB, Pergolizzi JV Jr, Taylor R Jr, et al. Acetaminophen (paracetamol) oral absorption and clinical influences. Pain Pract. 2014 Sep;14(7):668-77. doi: 10.1111/papr.12130.

  8. Mergenhagen KA, Wattengel BA, Skelly MK, et al. Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02167-19. doi: 10.1128/AAC.02167-19.

  9. Rivasi G, Menale S, Turrin G, et al. The Effects of Pain and Analgesic Medications on Blood Pressure. Curr Hypertens Rep. 2022 Oct;24(10):385-394. doi: 10.1007/s11906-022-01205-5.

  10. Hersh EV, Giannakopoulos H. Beta-adrenergic blocking agents and dental vasoconstrictors. Dent Clin North Am. 2010 Oct;54(4):687-96. doi: 10.1016/j.cden.2010.06.009.

  11. Daubländer M, Liebaug F, Niedeggen G, et al. Effectiveness and safety of phentolamine mesylate in routine dental care. J Am Dent Assoc. 2017 Mar;148(3):149-156. doi: 10.1016/j.adaj.2016.11.017.

  12. Amadi CN, Mgbahurike AA. Selected Food/Herb-Drug Interactions: Mechanisms and Clinical Relevance. Am J Ther. 2018 Jul/Aug;25(4):e423-e433. doi: 10.1097/MJT.0000000000000705.

  13. Guengerich FP. Drug metabolism. In: Golan DE, Armstrong EJ, Armstrong AW, eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 4th ed. Philadelphia, PA: Wolters Kluwer;2017:43-55.

  14. Council for International Organizations for Medical Sciences. Reporting adverse drug reactions. Definitions of terms and criteria for their use. Accessed October 10, 2025.

  15. Roswarski M, Villa KR, Kiersma ME, et al. Prevalence of Adverse Drug Effects/Adverse Drug Reactions in 200 Most Commonly Prescribed Drugs Corrected for Prescription Volume. Purdue University, School of Pharmacy and Pharmaceutical Sciences, West Lafayette, IN. Accessed October 10, 2025.

  16. National Institute of Health. U.S. National Library of Medicine. DailyMed. Accessed October 10, 2025.

  17. Centers for Disease Control and Prevention. Understanding the Opioid Overdose Epidemic. Accessed October 10, 2025.

  18. World Health Organization. Opioid Overdose, 4 August, 2021. Accessed October 10, 2025.

  19. Webster LR. Risk Factors for Opioid-Use Disorder and Overdose. Anesth Analg. 2017 Nov;125(5):1741-1748. doi: 10.1213/ANE.0000000000002496.

  20. Ciancio SG. Medications' impact on oral health. J Am Dent Assoc. 2004 Oct;135(10):1440-8; quiz 1468-9. doi: 10.14219/jada.archive.2004.0055

  21. Glick A, Sista V, Johnson C. Oral Manifestations of Commonly Prescribed Drugs. Am Fam Physician. 2020 Nov 15;102(10):613-621.

  22. Scully C, Bagan JV. Adverse drug reactions in the orofacial region. Crit Rev Oral Biol Med. 2004 Jul 1;15(4):221-39.

  23. Wolff A, Joshi RK, Ekström J, et al. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Drugs R D. 2017 Mar;17(1):1-28.

  24. Yuan A, Woo SB. Adverse drug events in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jan;119(1):35-47

  25. Drugs for postmenopausal osteoporosis. Med Lett Drugs Ther. 2024;66:105.

  26. Ruggiero SL, Dodson TB, Aghaloo T, et al. American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. J Oral Maxillofac Surg. 2022 May;80(5):920-943.

  27. Gottfried J. Nausea and Vomiting. Merck Manual Professional Version. Updated April 2025. Accessed October 10, 2025.

  28. Gottfried J. Diarrhea. Merck Manual Professional Version. Updated April 2025..Accessed October 10, 2025 .

  29. Gottfried J. Constipation. Merck Manual Professional Version. Updated April 2025. Accessed October 10, 2025.

  30. Ansari P. Acute Abdominal Pain. Merck Manual Professional Version. Updated July 2024. Accessed October 10, 2025.

  31. Vakil, N. Peptic Ulcer Disease. Merck Manual Professional Version. Updated January 2025. Accessed October 10, 2025.

  32. Farooq PD, Urrunaga NH, Tang DM, von Rosenvinge EC. Pseudomembranous colitis. Dis Mon. 2015 May;61(5):181-206.doi: 10.1016/j.disamonth.2015.01.006

  33. Gottfried J. Dyspepsia. Merck Manual Professional Version. Updated April 2025. Accessed October 10, 2025.

  34. FDA Drug Safety Communication: Prescription Acetaminophen Products to be Limited to 325 mg Per Dosage Unit; Boxed Warning Will Highlight Potential for Severe Liver Failure. 01/13/2011. Accessed October 10, 2025.

  35. Tholey D. Acute Liver Failure. Merck Manual Professional Version. Updated August 2025. Accessed October 10, 2025

  36. Altissimi G, Colizza A, Cianfrone G, et al. Drugs inducing hearing loss, tinnitus, dizziness and vertigo: an updated guide. Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):7946-7952. doi: 10.26355/eurrev_202008_22477.

  37. Ringer M, Hashmi MF, Lappin SL. Orthostatic Hypotension. In: StatPearls. Treasure Island (FL): StatPearls Publishing; January 17, 2025

  38. Grossman SA, Badireddy M. Syncope. [Updated 2025 Jun 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

  39. Goyal A, Robinson KJ, Katta S, et al. Palpitation(Archived) [Updated 2023 Apr 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

  40. Wexler RK, Pleister A, Raman S. Outpatient approach to palpitations. Am Fam Physician. 2011 Jul 1;84(1):63-9.

  41. Hashmi MF, Modi P, Basit H, et al. Dyspnea. [Updated 2023 Feb 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

  42. Ben-Noun L. Drug-induced respiratory disorders: incidence, prevention and management. Drug Saf. 2000 Aug;23(2):143-64. doi: 10.2165/00002018-200023020-00005.

  43. Keen MU, Aeddula NR. Analgesic Nephropathy. [Updated 2023 May 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

  44. Khandelwal C, Kistler C. Diagnosis of urinary incontinence. Am Fam Physician. 2013 Apr 15;87(8):543-50.

  45. D’Arrigo T. WebMD. What Medicines Can Make You Tired? Updated October 8, 2023.Accessed October 10, 2025.

  46. Shane-McWhorter L. Overview of Dietary Supplements. Merck Manual Professional Version. Updated July 2025. Accessed October 10, 2025.

  47. Schwab RJ. Insomnia and Excessive Daytime Sleepiness (EDS). Merck Manual Professional Version. Updated November 2024. Accessed October 10, 2025.

  48. Coryell W. Depressive Disorders. Merck Manual Professional Version. Updated 2025. Accessed October 10, 2025.

  49. Barnhill J. Overview of Anxiety Disorders. Merck Manual Professional Version. Updated January 2024. Accessed October 10, 2025.

  50. Silberstein SD. Approach to the Patient With Headache. Merck Manual Professional Version. Updated February 2025. Accessed October 10, 2025.

  51. Wassermann MR. Fatigue. Merck Manual Professional Version. Updated 2025. Accessed October 10, 2025.

  52. Rajput A.Raput A. Tremor. Merck Manual Professional Version. Updated June 2024. Accessed October 10, 20252023.

  53. Vasan S, Padhy RK. Tardive Dyskinesia. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

  54. Hammi C, Yeung B. Neuropathy. [Updated 2022 Oct 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

  55. Bush LM. Fever. Merck Manual Professional Version. Updated June 2025. Accessed October 10, 2025.

  56. Mathew P, Thoppil D. Hypoglycemia. [Updated 2022 Dec 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

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