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Methamphetamine: Implications for the Dental Team

Course Number: 332

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References / Additional References

  1. Clinical Guideline Committee. The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder. J Addict Med. 2024;18(1S Suppl 1):1-56. doi:10.1097/ADM.0000000000001299.

  2. U.S. Drug Enforcement Administration. 2025 National Drug Threat Assessment. Washington, DC: U.S. Department of Justice; 2025.

  3. National Institute on Drug Abuse. Methamphetamine. National Institutes of Health. Updated November 20, 2024. Accessed June 19, 2026.

  4. Substance Abuse and Mental Health Services Administration. Screening, Brief Intervention, and Referral to Treatment (SBIRT). Updated November 7, 2024. Accessed June 19, 2026.

  5. Office of National Drug Control Policy. Methamphetamine Plan Implementation Report. Executive Office of the President; 2024.

  6. Center for Behavioral Health Statistics and Quality. Key Substance Use and Mental Health Indicators in the United States: Results from the 2024 National Survey on Drug Use and Health. Substance Abuse and Mental Health Services Administration; 2025.

  7. Substance Abuse and Mental Health Services Administration. Using SAMHSA Funds to Implement Evidence-Based Contingency Management Services. SAMHSA Advisory. 2025.

  8. American Dental Association. Methamphetamine. ADA Oral Health Topics. Updated July 12, 2023. Accessed June 19, 2026.\

  9. Clague J, Belin TR, Shetty V. Mechanisms underlying methamphetamine-related dental disease. J Am Dent Assoc. 2017;148(6):377-386. doi:10.1016/j.adaj.2017.02.054.

  10. Shetty V, Harrell L, Murphy DA, et al. Dental disease patterns in methamphetamine users: findings in a large urban sample. J Am Dent Assoc. 2015;146(12):875-885. doi:10.1016/j.adaj.2015.09.012.

  11. Shetty V, Harrell L, Clague J, et al. Methamphetamine users have increased dental disease: a propensity score analysis. J Dent Res. 2016;95(7):814-821. doi:10.1177/0022034516645086.

  12. Spolsky VW, Clague J, Murphy DA, Vitero S, Dye BA, Belin TR, Shetty V. Periodontal status of current methamphetamine users. J Am Dent Assoc. 2018;149(3):174-183. doi:10.1016/j.adaj.2017.10.017.

  13. Nassar P, Ouanounou A. Cocaine and methamphetamine: pharmacology and dental implications. Can J Dent Hyg. 2020;54(2):75-82.

  14. Ravenel MC, Salinas CF, Marlow NM, Slate EH, Evans ZP, Miller PM. Methamphetamine abuse and oral health: a pilot study of “meth mouth.” Quintessence Int. 2012;43(3):229-237.

  15. Rommel N, Rohleder NH, Koerdt S, et al. Sympathomimetic effects of chronic methamphetamine abuse on oral health: a cross-sectional study. BMC Oral Health. 2016;16:59. doi:10.1186/s12903-016-0218-8.

  16. Shaner JW, Kimmes N, Saini T, Edwards P. “Meth mouth”: rampant caries in methamphetamine abusers. AIDS Patient Care STDS. 2006;20(3):146-150. doi:10.1089/apc.2006.20.146.

  17. Curtis EK. Meth mouth: a review of methamphetamine abuse and its oral manifestations. Gen Dent. 2006;54(2):125-129.

  18. Rhodus NL, Little JW. Methamphetamine abuse and “meth mouth.” Pa Dent J (Harrisb).2008;75(1):19-29.

  19. Trivedi MH, Walker R, Ling W, et al. Bupropion and naltrexone in methamphetamine use disorder. N Engl J Med. 2021;384(2):140-153. doi:10.1056/NEJMoa2020214.

  20. Courtney KE, Ray LA. Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend. 2014;143:11-21. doi:10.1016/j.drugalcdep.2014.08.003.

  21. Rawson RA. Current research on the epidemiology, medical and psychiatric effects, and treatment of methamphetamine use. J Food Drug Anal. 2013;21(4 Suppl):S77-S81. doi:10.1016/j.jfda.2013.09.037.

  22. Rawson RA, Huber A, Brethen P, et al. Status of methamphetamine users 2 to 5 years after outpatient treatment. J Addict Dis. 2002;21(1):107-119.

  23. Roll JM, Petry NM, Stitzer ML, et al. Contingency management for the treatment of methamphetamine use disorders. Am J Psychiatry. 2006;163(11):1993-1999.

  24. Walker R, Rosvall T, Field CA, et al. Disseminating contingency management to increase attendance in community substance abuse treatment centers. J Subst Abuse Treat. 2010;39(3):202-209. doi:10.1016/j.jsat.2010.05.010.

  25. Substance Abuse and Mental Health Services Administration. Using SAMHSA Funds to Implement Evidence-Based Contingency Management Services. Rockville, MD: SAMHSA; 2025.

  26. National Institute on Drug Abuse. Principles of Drug Addiction Treatment: A Research-Based Guide. 3rd ed. Bethesda, MD: National Institute on Drug Abuse; 2018.

  27. Clinical Guideline Committee. The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder. J Addict Med. 2024;18(1S Suppl 1):1-56. doi:10.1097/ADM.0000000000001299.

  28. Viswanath A, Barreveld AM, Fortino M. Assessment and management of the high-risk dental patient with active substance use disorder. Dent Clin North Am. 2020;64(3):547-558.

  29. Petit A, Karila L, Chalmin F, et al. Methamphetamine addiction: A review of the literature. J Addict Res Ther. 2012;S1:006. doi:10.4172/2155-6105.S1-006.

  30. U.S. Drug Enforcement Administration. 2025 National Drug Threat Assessment. Washington, DC: U.S. Department of Justice; 2025.

  31. Office of National Drug Control Policy. Methamphetamine Plan Implementation Report. Executive Office of the President; 2024.

  32. Freeman PR, Talbert J Impact of State Laws Regulating Pseudoephedrine on Methamphetamine Trafficking and Abuse. National Association of State Controlled Substance Authorities; 2012.

  33. United Nations Office on Drugs and Crime. World Drug Report 2025. Vienna: United Nations; 2025.

  34. Vearrier D, Greenberg MI, Miller SN, Okaneku JT, Haggerty DA. Methamphetamine: history, pathophysiology, adverse health effects, current trends, and hazards associated with the clandestine manufacture of methamphetamine. Dis Mon. 2012;58(2):38-89. doi:10.1016/j.disamonth.2011.09.004.

  35. Irvine GD, Chin L. The environmental impact and adverse health effects of the clandestine manufacture of methamphetamine. NIDA Res Monogr. 1991;115:33-46.

  36. U.S. Environmental Protection Agency. Voluntary Guidelines for Methamphetamine and Fentanyl Laboratory Cleanup. Revised ed. Washington, DC: U.S. Environmental Protection Agency; 2021.

  37. Wisconsin Department of Health Services. Assessing and Ordering Methamphetamine Laboratory Cleanup. Wisconsin Department of Health Services; 2018.

  38. Child Welfare Information Gateway. Parental Substance Use as Child Maltreatment. U.S. Department of Health and Human Services, Administration for Children and Families, Children’s Bureau.

  39. Chang L, Ernst T, Speck O, et al. Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities. Am J Psychiatry. 2005;162(2):361-369.

  40. Rippeth JD, Heaton RK, Carey CL, et al. Methamphetamine dependence increases risk of neuropsychological impairment in HIV-infected persons. J Int Neuropsychol Soc. 2004;10(1):1-14.

  41. Rusyniak DE. Neurologic manifestations of chronic methamphetamine abuse. Psychiatr Clin North Am. 2013;36(2):261-275. doi:10.1016/j.psc.2013.02.005.

  42. Gonzales R, Ang A, Marinelli-Casey P, et al. Health-related quality-of-life trajectories of methamphetamine-dependent individuals after treatment. J Subst Abuse Treat. 2009;37(4):353-361.

  43. Kelly BC, LeClair A, Parsons JT. Methamphetamine use among urban populations and associated behavioral risk factors. Subst Use Misuse. 2013;48(14):1541-1552.

  44. Quaranta A, D'Isidoro O, Piattelli A, et al. Illegal drugs and periodontal conditions. Periodontol 2000. 2022;90(1):62-87. doi:10.1111/prd.12450.

  45. American Dental Association. Oral Health Topics: Substance Use Disorders and Oral Health. American Dental Association.

Additional Resources

  • National Institute on Drug Abuse (NIDA)

  • SAMHSA

  • American Society of Addiction Medicine (ASAM)

  • Centers for Disease Control and Prevention (CDC)

  • American Dental Association (ADA)

  • Drug Enforcement Administration (DEA)

  • Office of National Drug Control Policy (ONDCP)

  • Journal of the American Dental Association (JADA)

  • Journal of Dental Research

  • Journal of Evidence-Based Dental Practice

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